Astrocytic reprogramming combined with rehabilitation strategy improves recovery from spinal cord injury

T Yang, L Xing, W Yu, Y Cai, S Cui… - The FASEB …, 2020 - Wiley Online Library
After spinal cord injury (SCI), the irreversible loss of neurons and the dense glial scar are
two of the leading causes of axon regeneration failure. The adult mammalian spinal cord …

Clinical-like cryotherapy improves footprint patterns and reduces synovial inflammation in a rat model of post-traumatic knee osteoarthritis

GM Barbosa, JE Cunha, TM Cunha, LB Martinho… - Scientific Reports, 2019 - nature.com
Cryotherapy is a non-pharmacological treatment commonly used to control inflammation
and improve function after acute traumas. However, there are no definitive findings about its …

Preservation of functional descending input to paralyzed upper extremity muscles in motor complete cervical spinal cord injury

P Sharma, A Naglah, S Aslan, F Khalifa, A El-Baz… - Clinical …, 2023 - Elsevier
Objective Spinal cord injury (SCI) is classified as complete or incomplete depending on the
extent of sensorimotor preservation below the injury level. However, individuals with …

In vivo electrophysiological mechanisms underlying cervical epidural stimulation in adult rats

P Sharma, PK Shah - The Journal of Physiology, 2021 - Wiley Online Library
Key points To electrophysiologically determine the predominant neural structures activated
with cervical epidural stimulation (ES), well‐established electrophysiological protocols …

Novel comprehensive analysis of skilled reaching and grasping behavior in adult rats

P Sharma, Y Du, K Singapuri, DM Delafraz… - Journal of Neuroscience …, 2024 - Elsevier
Background Reaching and grasping (R&G) in rats is commonly used as an outcome
measure to investigate the effectiveness of rehabilitation or treatment strategies to recover …

Regenerative Potential of Platelet-Rich Fibrin Releasate Combined with Adipose Tissue–Derived Stem Cells in a Rat Sciatic Nerve Injury Model

MH Chuang, LH Ho, TF Kuo, SY Sheu… - Cell …, 2020 - journals.sagepub.com
Sciatic nerve injuries, not uncommon in trauma with a limited degree of functional recovery,
are considered a persistent clinical, social, and economic problem worldwide. Accumulating …

Exercise recovers weight gain, but not increased impulsive choice, caused by a high-fat diet

KF Wilson, AE Fox - Appetite, 2024 - Elsevier
A high-fat diet has negative effects on physical, neurological, and behavioral outcomes. One
consistent finding is that a diet high in fat increases impulsive choice behavior—behavior …

Repeated epidural stimulation modulates cervical spinal cord excitability in healthy adult rats

P Sharma, H Rampersaud, PK Shah - Experimental Brain Research, 2025 - Springer
Spinal evoked motor responses (SEMR) are utilized in longitudinal pre-clinical and human
studies to reflect the in-vivo physiological changes in neural networks secondary to a spinal …

Cervical Spinal Cord Modulation with Repeated Epidural Stimulation in Healthy Adult Rats

P Sharma, H Rampersaud, PK Shah - bioRxiv, 2022 - biorxiv.org
The effects of spinal epidural stimulation (ES) in regaining various physiological functions
after a spinal cord injury (SCI) are well documented. Spinal evoked motor responses …

Activity-Dependent Spinal Epidural Stimulation to Promote Recovery of Skilled Upper Limb Function after a Spinal Cord Injury

P Sharma - 2021 - search.proquest.com
Lack of independence resulting from impaired upper limb function substantially
compromises the quality of life of persons with a cervical spinal cord injury (SCI) …