An understanding of the process by which tumor cells destroy the basement membrane of
the surface epithelium, invade, and metastasize is essential to the development of novel …

There is increasing evidence that a variety of cancers arise from transformation of normal
stem cells to cancer stem cells (CSCs). CSCs are thought to sustain cancer progression …

Squamous cell carcinoma in the head and neck (HNSCC) is a common yet poorly
understood cancer, with adverse clinical outcomes due to treatment resistance, recurrence …

Background There is a great interest in developing biomarkers to enhance early detection
and clinical management of tongue squamous cell carcinoma (TSCC). However, the …

B-cell-specific Moloney murine leukemia virus integration region 1 (Bmi-1, also known as
RNF51 or PCGF4) is one of the important members of the PcG gene family, and is involved …

Head and neck squamous cell carcinoma (HNSCC) is the sixth most commonly diagnosed
cancer worldwide. Despite advances in the treatment management, locally advanced …

Crosstalk between tumor and stromal cells in the tumor microenvironment alter its properties
in ways that facilitate the invasive behavior of tumor cells. Here, we demonstrate that cancer …

The identification and characterization of stem cells is a major focus of developmental
biology and regenerative medicine. The advent of genetic inducible fate mapping …

Head and neck squamous cell carcinoma (HNSCC) is one of the world's top ten most
common cancers. Current survival rates are poor with only 50% of patients expected to …

Most cancers contain a small sub-population of cells that are endowed with self-renewal,
multipotency, and a unique potential for tumor initiation. These properties are considered …