Tuberculosis (TB), caused by the intracellular pathogen Mycobacterium tuberculosis,
remains one of the leading causes of mortality across the world. There is an urgent …

Mycobacterium tuberculosis remains one of the most successful bacterial pathogens,
claiming over 1.3 million lives worldwide in 2013. The emergence of multidrug-resistant and …

Microorganisms that invade a vertebrate host are initially recognized by the innate immune
system through germline-encoded pattern-recognition receptors (PRRs). Several classes of …

Bacterial capsules have evolved to be at the forefront of the cell envelope, making them an
essential element of bacterial biology. Efforts to understand the Mycobacterium tuberculosis …

The cell wall component lipoarabinomannan (ManLAM) from Mycobacterium tuberculosis is
involved in the inhibition of phagosome maturation, apoptosis and interferon (IFN)‐γ …

Contact of Mycobacterium tuberculosis (M. tb) with the immune system requires interactions
between microbial surface molecules and host pattern recognition receptors. Major M. tb …

Approximately one third of the world's population is infected with Mycobacterium
tuberculosis, the causative agent of tuberculosis. This bacterium has an unusual lipid-rich …

Microbial challenges to the host initiate an array of defense processes through the activation
of innate and adaptive immunity. Innate immunity consists of sensors or pattern-recognition …

MyD88, the common adapter involved in TLR, IL-1, and IL-18 receptor signaling, is essential
for the control of acute Mycobacterium tuberculosis (MTB) infection. Although TLR2, TLR4 …

Infection with Mycobacterium tuberculosis is one of the leading causes of death worldwide.
Recognition of M. tuberculosis by pattern recognition receptors is crucial for activation of …