[HTML][HTML] Glutathione catalysis and the reaction mechanisms of glutathione-dependent enzymes
M Deponte - Biochimica et Biophysica Acta (BBA)-General Subjects, 2013 - Elsevier
BACKGROUND: Glutathione-dependent catalysis is a metabolic adaptation to chemical
challenges encountered by all life forms. In the course of evolution, nature optimized …
challenges encountered by all life forms. In the course of evolution, nature optimized …
Enzymes of the cyclooxygenase pathways of prostanoid biosynthesis
WL Smith, Y Urade, PJ Jakobsson - Chemical reviews, 2011 - ACS Publications
Prostanoids are cyclic, oxygenated products ofω3 andω6 20-and 22-carbon essential fatty
acids (FAs) that are formed enzymatically through “cyclooxygenases”. Prostaglandin …
acids (FAs) that are formed enzymatically through “cyclooxygenases”. Prostaglandin …
Mechanisms of induction of cytosolic and microsomal glutathione transferase (GST) genes by xenobiotics and pro-inflammatory agents
LG Higgins, JD Hayes - Drug metabolism reviews, 2011 - Taylor & Francis
Glutathione transferase (GST) isoezymes are encoded by three separate families of genes
(designated cytosolic, microsomal and mitochondrial transferases), with distinct evolutionary …
(designated cytosolic, microsomal and mitochondrial transferases), with distinct evolutionary …
Perspective of microsomal prostaglandin E2 synthase-1 as drug target in inflammation-related disorders
A Koeberle, O Werz - Biochemical pharmacology, 2015 - Elsevier
Prostaglandin (PG) E 2 encompasses crucial roles in pain, fever, inflammation and diseases
with inflammatory component, such as cancer, but is also essential for gastric, renal …
with inflammatory component, such as cancer, but is also essential for gastric, renal …
A review on mPGES-1 inhibitors: From preclinical studies to clinical applications
F Bergqvist, R Morgenstern, PJ Jakobsson - Prostaglandins & other lipid …, 2020 - Elsevier
Abstract Prostaglandin E 2 (PGE 2) is a lipid mediator of inflammation and cancer
progression. It is mainly formed via metabolism of arachidonic acid by cyclooxygenases …
progression. It is mainly formed via metabolism of arachidonic acid by cyclooxygenases …
Crystal structure of microsomal prostaglandin E2 synthase provides insight into diversity in the MAPEG superfamily
Prostaglandin E2 (PGE2) is a key mediator in inflammatory response. The main source of
inducible PGE2, microsomal PGE2 synthase-1 (mPGES-1), has emerged as an interesting …
inducible PGE2, microsomal PGE2 synthase-1 (mPGES-1), has emerged as an interesting …
[HTML][HTML] Inhibition of microsomal prostaglandin E synthase-1 in cancer-associated fibroblasts suppresses neuroblastoma tumor growth
A Kock, K Larsson, F Bergqvist, N Eissler… - …, 2018 - thelancet.com
Despite recent progress in diagnosis and treatment, survival for children with high-risk
metastatic neuroblastoma is still poor. Prostaglandin E 2 (PGE 2)-driven inflammation …
metastatic neuroblastoma is still poor. Prostaglandin E 2 (PGE 2)-driven inflammation …
Microsomal glutathione transferase 1: mechanism and functional roles
R Morgenstern, J Zhang, K Johansson - Drug metabolism reviews, 2011 - Taylor & Francis
Microsomal glutathione transferase 1 (MGST1) belongs to a superfamily named MAPEG
(membrane-associated proteins in eicosanoid and glutathione metabolism). This family is …
(membrane-associated proteins in eicosanoid and glutathione metabolism). This family is …
Identification and development of mPGES-1 inhibitors: where we are at?
HH Chang, EJ Meuillet - Future medicinal chemistry, 2011 - Taylor & Francis
Microsomal prostaglandin E synthase-1 (mPGES-1) is the terminal synthase responsible for
the synthesis of the pro-tumorigenic prostaglandin E2 (PGE2). mPGES-1 is overexpressed …
the synthesis of the pro-tumorigenic prostaglandin E2 (PGE2). mPGES-1 is overexpressed …
Natural products as inhibitors of prostaglandin E2 and pro-inflammatory 5-lipoxygenase-derived lipid mediator biosynthesis
A Koeberle, O Werz - Biotechnology advances, 2018 - Elsevier
Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit prostanoid formation and represent
prevalent therapeutics for treatment of inflammatory disorders. However, NSAIDs are …
prevalent therapeutics for treatment of inflammatory disorders. However, NSAIDs are …