Currently, enhancement of cholinergic neurotransmission via cholinesterase inhibitors
represents the main available approach to treat cognitive and behavioural symptoms of the …

Schizophrenia remains a challenging disease to treat effectively with current antipsychotic
medications due to their limited efficacy across the entire spectrum of core symptoms as well …

Since its discovery, nerve growth factor (NGF) has long occupied a critical role in
developmental and adult neurobiology for its many important regulatory functions on the …

Sjögren's syndrome is a chronic autoimmune disorder of the exocrine glands with
associated lymphocytic infiltrates of the affected glands. Dryness of the mouth and eyes …

Actions of acetylcholine in the periphery are the result of activation of either the ionotropic
nicotinic receptor or the metabotropic muscarinic receptor. In the mammalian central …

Muscarinic acetylcholine receptors (mAChRs) are widely expressed in the CNS where they
control a variety of neuronal functions. Due to their roles in a number of CNS processes …

Neurotrophic factors (NTF) are small, versatile proteins that maintain survival and function to
specific neuronal populations. In general, the axonal transport of NTF is important as not all …

Muscarinic acetylcholine receptors (mAChRs; M1–M5) play key roles in regulating the
activity of many important functions of the central and peripheral nervous system. Because of …

Members of the muscarinic acetylcholine receptor family are thought to play key roles in the
regulation of a large number of important functions of the CNS. However, the precise roles of …

The M1 and M4 muscarinic acetylcholine receptors (mAChRs) are highly pursued drug
targets for neurological diseases, in particular for Alzheimer's disease and schizophrenia …