The protease 3C is encoded by all known picornaviruses, and the structural features related
to its protease and RNA-binding activities are conserved; these contribute to the cleavage of …

The Picornaviridae family comprises a large group of non-enveloped viruses with enormous
impact on human and animal health. The picornaviral genome contains one open reading …

Background The quasi-enveloped picornavirus, Hepatitis A Virus (HAV), causes acute
hepatitis in humans and infects approximately 1.5 million individuals a year, which does not …

Hepatitis A virus (HAV) infection is a major cause of acute hepatitis worldwide and
occasionally causes acute liver failure and can lead to death in the absence of liver …

Hepatitis A virus (HAV) infection is one of the major causes of acute hepatitis, and this
infection occasionally causes acute liver failure. HAV infection is associated with HAV …

Viruses with positive-sense single stranded RNA (+ ssRNA) genomes are responsible for
different diseases and represent a global health problem. In addition to developing new …

Two series of flavonoid hybrids, totaling 42 compounds, were designed, synthesized and
evaluated to develop antiviral compounds effective against hepatitis A virus (HAV). A …

Cavally virus (CavV) is a mosquito-borne plus-strand RNA virus in the family Mesoniviridae
(order Nidovirales). We present X-ray structures for the CavV 3C-like protease (3CL pro), as …

A thiazole-based chalconoid ligand (E)-3-(2-hydroxyphenyl)-1-(thiazol-2-yl) prop-2-en-1-
one (HPTP) and its Co (II), Ni (II), Cu (II) and Zn (II) complexes have been synthesized. The …

Big data generation through sequencing of genomes and proteomes has led to over
thousands of whole genomes and millions of protein sequences. However, utilization of this …