Glycolysis is a tightly regulated process in which several enzymes, such as Hexokinases
(HKs), play crucial roles. Cancer cells are characterized by specific expression levels of …

Nitro group containing xenobiotics include drugs, cancer chemotherapeutic agents,
carcinogens (eg, nitroarenes and aristolochic acid) and explosives. The nitro group …

Mitochondrial metabolites regulate leukaemic and normal stem cells by affecting epigenetic
marks. How mitochondrial enzymes localize to the nucleus to control stem cell function is …

Moonlighting proteins are defined as proteins with two or more functions that are unrelated
and independent to each other, so that inactivation of one of them should not affect the …

Glucose metabolism is indispensable for cell growth and survival. Hexokinases play pivotal
roles in glucose metabolism through canonical functions of hexokinases as well as in …

Cortex fraxini is a widely used traditional Chinese medicine. Esculin is one of the main
active ingredients of Cortex fraxini and has attracted more and more attention from scholars …

Abstract N6-methyladenosine (m6A) has been identified to exert critical roles in human
cancer; however, the regulation of m6A modification on glioblastoma multiforme (GBM) and …

Glioblastoma multiforme (GBM) is one of the most recalcitrant brain tumors characterized by
a tumor microenvironment (TME) that strongly supports GBM growth, aggressiveness …

Glioma cells use intermediate levels of reactive oxygen species (ROS) and reactive nitrogen
species (RNS) for growth and invasion, and suppressing these reactive molecules thus may …

Glioma is the most common and aggressive tumor of the central nervous system. The
uncontrolled proliferation, cellular heterogeneity, and diffusive capacity of glioma cells …