A cocktail of protective antibodies subverts the dense glycan shield of Lassa virus

H Li, T Buck, M Zandonatti, J Yin… - Science translational …, 2022 - science.org
Developing potent therapeutics and effective vaccines are the ultimate goals in controlling
infectious diseases. Lassa virus (LASV), the causative pathogen of Lassa fever (LF), infects …

Cleavage-intermediate Lassa virus trimer elicits neutralizing responses, identifies neutralizing nanobodies, and reveals an apex-situated site-of-vulnerability

J Gorman, CSF Cheung, Z Duan, L Ou, M Wang… - Nature …, 2024 - nature.com
Lassa virus (LASV) infection is expanding outside its traditionally endemic areas in West
Africa, posing a pandemic biothreat. LASV-neutralizing antibodies, moreover, have proven …

The Adaptive Immune Response against Bunyavirales

R Alatrash, BB Herrera - Viruses, 2024 - mdpi.com
The Bunyavirales order includes at least fourteen families with diverse but related viruses,
which are transmitted to vertebrate hosts by arthropod or rodent vectors. These viruses are …

Neutralizing antibodies against Lassa virus lineage I

TK Buck, AS Enriquez, SL Schendel, MA Zandonatti… - MBio, 2022 - Am Soc Microbiol
Lassa virus (LASV) is the causative agent of the deadly Lassa fever (LF). Seven distinct
LASV lineages circulate through western Africa, among which lineage I (LI), the first to be …

Entry inhibitors as arenavirus antivirals

K Iyer, Z Yan, SR Ross - Frontiers in Microbiology, 2024 - frontiersin.org
Arenaviruses belonging to the Arenaviridae family, genus mammarenavirus, are enveloped,
single-stranded RNA viruses primarily found in rodent species, that cause severe …

Structural conservation of Lassa virus glycoproteins and recognition by neutralizing antibodies

HR Perrett, PJM Brouwer, J Hurtado, ML Newby, L Liu… - Cell reports, 2023 - cell.com
Lassa fever is an acute hemorrhagic fever caused by the zoonotic Lassa virus (LASV). The
LASV glycoprotein complex (GPC) mediates viral entry and is the sole target for neutralizing …

Structural basis for antibody-mediated neutralization of lymphocytic choriomeningitis virus

A Moon-Walker, Z Zhang, DS Zyla, TK Buck, H Li… - Cell chemical …, 2023 - cell.com
The mammarenavirus lymphocytic choriomeningitis virus (LCMV) is a globally distributed
zoonotic pathogen that can be lethal in immunocompromised patients and can cause severe …

Deep mutational scanning reveals functional constraints and antibody-escape potential of Lassa virus glycoprotein complex

CR Carr, KHD Crawford, M Murphy, JG Galloway… - Immunity, 2024 - cell.com
Lassa virus is estimated to cause thousands of human deaths per year, primarily due to
spillovers from its natural host, Mastomys rodents. Efforts to create vaccines and antibody …

Lessons from the pandemic: Responding to emerging zoonotic viral diseases—a Keystone Symposia report

J Cable, A Fauci, WE Dowling… - Annals of the New …, 2022 - Wiley Online Library
The COVID‐19 pandemic caught the world largely unprepared, including scientific and
policy communities. On April 10–13, 2022, researchers across academia, industry …

Spatio-temporal spread and evolution of Lassa virus in West Africa

X Wang, X Ye, R Li, X Zai, M Hu, S Wang, H Ren… - BMC Infectious …, 2024 - Springer
Background Lassa fever is a hemorrhagic disease caused by Lassa virus (LASV), which has
been classified by the World Health Organization as one of the top infectious diseases …