Neuroaxonal damage is the pathological substrate of permanent disability in various
neurological disorders. Reliable quantification and longitudinal follow-up of such damage …

Importance Neurofilament light protein (NfL) is elevated in cerebrospinal fluid (CSF) of a
number of neurological conditions compared with healthy controls (HC) and is a candidate …

Interest in neurofilaments has risen sharply in recent years with recognition of their potential
as biomarkers of brain injury or neurodegeneration in CSF and blood. This is in the context …

Background Rater agreement is important in clinical research, and Cohen's Kappa is a
widely used method for assessing inter-rater reliability; however, there are well documented …

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two related
currently incurable neurodegenerative diseases. ALS is characterized by degeneration of …

Objective To evaluate cerebrospinal fluid (CSF) and serum neurofilament light chain (NfL)
levels in genetic frontotemporal dementia (FTD) as a potential biomarker in the …

Importance A clearer definition of the role of neurofilament light chain (NFL) as a biomarker
in amyotrophic lateral sclerosis (ALS) is needed. Objectives To assess the ability of NFL to …

With the contribution from more than one hundred CNS neurotrauma experts, this book
provides a comprehensive and up-to-date account on the latest developments in the area of …

Motor neuron diseases (MNDs) are etiologically and biologically heterogeneous diseases.
The pathobiology of motor neuron degeneration is still largely unknown, and no effective …

Diagnosis of multiple sclerosis (MS) requires the exclusion of other possible diagnoses. For
this reason, the cerebrospinal fluid (CSF) should be routinely analysed in patients with a first …