▪ Abstract The maintenance of the eukaryotic genome requires precisely coordinated
replication of the entire genome each time a cell divides. To achieve this coordination …

The cyclin dependent kinase Cdk1 controls the cell cycle, which is best understood in the
model organism S. cerevisiae. Research performed during the past decade has significantly …

The adaptive responses of a living cell to internal and external signals are controlled by
networks of proteins whose interactions are so complex that the functional integration of the …

DNA replication is tightly controlled in eukaryotic cells to ensure that an exact copy of the
genetic material is inherited by both daughter cells. Oscillating waves of cyclin-dependent …

Cyclin degradation is central to regulation of the cell cycle. Mitotic exit was proposed to
require degradation of the S phase cyclin Clb5 by the anaphase-promoting complex …

To maintain genome integrity in eukaryotes, DNA must be duplicated precisely once before
cell division occurs. A process called replication licensing ensures that chromosomes are …

G 1 cell cycle regulators are often mutated in cancer, but how this causes genomic instability
is unclear. Here we show that yeast lacking the CDK inhibitor Sic1 initiate DNA replication …

Cyclin-dependent kinases (CDKs) coordinate hundreds of molecular events during the cell
cycle. Multiple cyclins are involved, but the global role of cyclin-specific phosphorylation has …

Before S phase, cells license replication origins for initiation by loading them with Mcm2-7
heterohexamers. This process is dependent on Cdc6, which is recruited to unlicensed …

Recently, mutations of the additional sex comb-like 1 (ASXL1) gene were identified in
patients with myelodysplastic syndrome (MDS), but the interaction of this mutation with other …