The release and absorption profile of an oral medication is influenced by the
physicochemical properties of the drug and its formulation, as well as by the anatomy and …

Model-informed precision dosing (MIPD) has become synonymous with modern approaches
for individualizing drug therapy, in which the characteristics of each patient are considered …

The value of in silico methods in drug development and evaluation has been demonstrated
repeatedly and convincingly. While their benefits are now unanimously recognized …

The immunosuppressive agent mycophenolate is used extensively in kidney transplantation,
yet dosing strategy applied varies markedly from fixed dosing (“one-dose-fits-all”), to …

Background and objective External evaluation is an important issue in the population
pharmacokinetic analysis of antibiotics. The purpose of this review was to summarize the …

Aims This study aims to assess approaches to handle interoccasion variability (IOV) in a
model‐based therapeutic drug monitoring (TDM) context, using a population …

The current antimicrobial therapy of bacterial infections of the central nervous system (CNS)
in adults and pediatric patients is faced with many pitfalls as the drugs have to reach …

A rare disease is defined as a condition affecting fewer than 200 000 people in the United
States by the Orphan Drug Act. For rare diseases, it is challenging to enroll a large number …

The current demand for pharmacometricians outmatches the supply provided by academic
institutions and considerable investments are made to develop the competencies of these …

Lean body mass is commonly proposed for anesthesia maintenance drug dosing
calculations. However, total body mass used with allometric scaling has been shown to be …