Worldwide, the incidence of major depressive disorder (MDD) is increasing annually,
resulting in greater economic and social burdens. Moreover, the pathological mechanisms …

Mitochondria are complex endosymbionts that evolved from primordial purple nonsulfur
bacteria. The incorporation of bacteria-derived mitochondria facilitates a more efficient and …

A growing body of research suggests that social or physical activity can affect the risk of
Major depressive disorder (MDD). However, the bidirectional relationship between them …

Background Obesity have been showed to be strongly associated with psychiatric disorders,
but the exact causality and the direction of the relationship remain inconclusive. Thus, we …

Polyphenols are natural compounds also contained in daily consumed foods that show their
efficacy in different clinical fields. Both pre-clinical and clinical studies demonstrated that …

Abstract Major Depressive Disorder (MDD) is marked by abnormal brain function and
elevated plasma oxidative stress markers. The specific relationship between these factors in …

Lithium is one of the most effect mood-stabilizing drugs prescribed especially for bipolar
disorder. Lithium has wide range effects on different molecular factors and neural …

Background: Although oxidative stress is known to contribute to cancer, and endogenous
and exogenous antioxidants are thought to prevent tumorigenesis by suppressing oxidative …

Background Although well-documented, the causal relationships between diet-derived
circulating antioxidants, oxidative stress, and osteoarthritis (OA) are equivocal. The objective …

Redox regulatory drug (RRD) targets may be considered potential novel drug targets of
psychosis due to the fact that the brain is highly susceptible to oxidative stress imbalance …