[HTML][HTML] Impact of respiratory dust on health: A comparison based on the toxicity of PM2. 5, silica, and nanosilica

A Hu, R Li, G Chen, S Chen - International Journal of Molecular Sciences, 2024 - mdpi.com
Respiratory dust of different particle sizes in the environment causes diverse health effects
when entering the human body and makes acute or chronic damage through multiple …

Crosstalk between fibroblasts and immunocytes in fibrosis: From molecular mechanisms to clinical trials

X Di, J Chen, Y Li, M Wang, J Wei, T Li… - Clinical and …, 2024 - Wiley Online Library
Background The impact of fibroblasts on the immune system provides insight into the
function of fibroblasts. In various tissue microenvironments, multiple fibroblast subtypes …

Crystalline silica-induced endoplasmic reticulum stress promotes the pathogenesis of silicosis by augmenting proinflammatory interstitial pulmonary macrophages

H Yuan, Y He, Y Zhang, H Min, J Chen, C Li - Science of The Total …, 2024 - Elsevier
Crystalline silica (CS) particles are ubiquitously present in the environment, particularly in
occupational settings, and exposure to respirable CS causes silicosis, imposing a significant …

Single-cell RNA sequencing in donor and end-stage heart failure patients identifies NLRP3 as a therapeutic target for arrhythmogenic right ventricular cardiomyopathy

M Fu, X Hua, S Shu, X Xu, H Zhang, Z Peng, H Mo… - BMC medicine, 2024 - Springer
Background Dilation may be the first right ventricular change and accelerates the
progression of threatening ventricular tachyarrhythmias and heart failure for patients with …

Extracellular-vesicle-packaged S100A11 from osteosarcoma cells mediates lung premetastatic niche formation by recruiting gMDSCs

C Deng, Y Xu, H Chen, X Zhu, L Huang, Z Chen, H Xu… - Cell Reports, 2024 - cell.com
The premetastatic niche (PMN) contributes to lung-specific metastatic tropism in
osteosarcoma. However, the crosstalk between primary tumor cells and lung stromal cells is …

Mechanics-activated fibroblasts promote pulmonary group 2 innate lymphoid cell plasticity propelling silicosis progression

Y He, F Yang, L Yang, H Yuan, Y You, Y Chen… - Nature …, 2024 - nature.com
Crystalline silica (CS) particle exposure leads to silicosis which is characterized as
progressive fibrosis. Fibroblasts are vital effector cells in fibrogenesis. Emerging studies …

Deciphering the spatial organization of fibrotic microenvironment in silica particles-induced pulmonary fibrosis

L Yang, X Wei, P Sun, J Wang, X Zhou, X Zhang… - Journal of Hazardous …, 2024 - Elsevier
Silicosis represents a form of interstitial lung disease induced by the inhalation of silica
particles in production environments. A key pathological characteristic of silica-induced …

[HTML][HTML] Silica's silent threat: Contributing to skin fibrosis in systemic sclerosis by targeting the HDAC4/Smad2/3 pathway

B Tang, Y Shi, Z Zeng, X He, J Yu, K Chai, J Liu… - Environmental …, 2024 - Elsevier
Nowadays, silica products are widely used in daily life, especially in skin applications, which
inevitably increases the risk of silica exposure in general population. However, inadequate …

Quercetin Protects against Silicon dioxide Particles-induced spleen ZBP1-Mediated PANoptosis by regulating the Nrf2/Drp1/mtDNA axis

K Li, X Yang, T Xu, X Shi, S Xu - International Immunopharmacology, 2024 - Elsevier
Silicon dioxide particles (SiO 2) are a widely used novel material, and SiO 2 that enter the
body can accumulate in the spleen and cause spleen injury. Quercetin (Que) has a strong …

A network pharmacology approach-based decoding of Resveratrol's anti-fibrotic mechanisms

Y Wang, N Li, J Hu, Y Zhao, W Zhou, S Li, G Yi, H Bian… - Phytomedicine, 2024 - Elsevier
Background Inhalation of crystalline silica (CS) frequently leads to chronic lung inflammation
and pulmonary fibrosis (PF), a condition with limited effective treatments. Resveratrol (Res) …