[HTML][HTML] Therapeutic strategies for COVID-19: progress and lessons learned
G Li, R Hilgenfeld, R Whitley, E De Clercq - Nature Reviews Drug …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …
[HTML][HTML] Targetable elements in SARS-CoV-2 S2 subunit for the design of pan-coronavirus fusion inhibitors and vaccines
L Guo, S Lin, Z Chen, Y Cao, B He, G Lu - Signal Transduction and …, 2023 - nature.com
The ongoing global pandemic of coronavirus disease 2019 (COVID-19), caused by severe
acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has caused devastating impacts …
acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has caused devastating impacts …
Antigenicity and infectivity characterisation of SARS-CoV-2 BA. 2.86
S Yang, Y Yu, F Jian, W Song, A Yisimayi… - The Lancet Infectious …, 2023 - thelancet.com
The newly emerged SARS-CoV-2 saltation variant, BA. 2.86, has raised global concern
(appendix 1 p 7). By Sept 8, 2023, 95 sequences were detected, of which their early …
(appendix 1 p 7). By Sept 8, 2023, 95 sequences were detected, of which their early …
[HTML][HTML] Prefusion-stabilized SARS-CoV-2 S2-only antigen provides protection against SARS-CoV-2 challenge
Abstract Ever-evolving SARS-CoV-2 variants of concern (VOCs) have diminished the
effectiveness of therapeutic antibodies and vaccines. Developing a coronavirus vaccine that …
effectiveness of therapeutic antibodies and vaccines. Developing a coronavirus vaccine that …
[HTML][HTML] Broadly neutralizing antibodies against COVID-19
The COVID-19 pandemic caused by SARS-CoV-2 has led to hundreds of millions of
infections and millions of deaths, however, human monoclonal antibodies (mAbs) can be an …
infections and millions of deaths, however, human monoclonal antibodies (mAbs) can be an …
Low-sugar universal mRNA vaccine against coronavirus variants with deletion of glycosites in the S2 or stem of SARS-CoV-2 spike messenger RNA (mRNA)
CW Cheng, CY Wu, SW Wang… - Proceedings of the …, 2023 - National Acad Sciences
Since the outbreak of Severe Acute Respiratory Syndrome Virus-2 (SARS-CoV-2) in 2019,
more than 15 million spike protein sequences have been identified, raising a new challenge …
more than 15 million spike protein sequences have been identified, raising a new challenge …
Conversion of monoclonal IgG to dimeric and secretory IgA restores neutralizing ability and prevents infection of Omicron lineages
The emergence of Omicron lineages and descendent subvariants continues to present a
severe threat to the effectiveness of vaccines and therapeutic antibodies. We have …
severe threat to the effectiveness of vaccines and therapeutic antibodies. We have …
[HTML][HTML] The SARS-CoV-2 neutralizing antibody response to SD1 and its evasion by BA. 2.86
Under pressure from neutralising antibodies induced by vaccination or infection the SARS-
CoV-2 spike gene has become a hotspot for evolutionary change, leading to the failure of all …
CoV-2 spike gene has become a hotspot for evolutionary change, leading to the failure of all …
[HTML][HTML] Structural understanding of SARS-CoV-2 virus entry to host cells
K Le, S Kannappan, T Kim, JH Lee, HR Lee… - Frontiers in Molecular …, 2023 - frontiersin.org
Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), is a major global health concern associated with millions of …
coronavirus 2 (SARS-CoV-2), is a major global health concern associated with millions of …
[HTML][HTML] Functional and antigenic characterization of SARS-CoV-2 spike fusion peptide by deep mutational scanning
The fusion peptide of SARS-CoV-2 spike protein is functionally important for membrane
fusion during virus entry and is part of a broadly neutralizing epitope. However, sequence …
fusion during virus entry and is part of a broadly neutralizing epitope. However, sequence …