The kidney is a complex organ that performs essential functions such as blood filtration and
fluid homeostasis, among others. Recent years have heralded significant advancements in …

Congenital anomalies of the kidney and urinary tract (CAKUT) occur in∼ 1/500 live births
and are a leading cause of pediatric kidney failure. With an average wait time of 3-5 years …

Kidney disease is a devastating condition affecting millions of people worldwide, where over
100,000 patients in the United States alone remain waiting for a lifesaving organ transplant …

Abstract Purpose Haploinsufficiency of DYRK1A causes a recognizable clinical syndrome.
The goal of this paper is to investigate congenital anomalies of the kidney and urinary tract …

The CRISPR/Cas9 method has become popular for gene disruption experiments in
Xenopus laevis. However, the experimental conditions that influence the efficiency of …

Xenopus laevis frogs are a powerful developmental model that enables studies combining
classical embryology and molecular manipulation. Because of the large embryo size, ease …

The recently proposed idea of" urocrine signaling" hypothesizes that small secreted
extracellular vesicles (EVs) contain proteins that transmit signals to distant cells. However …

Kidneys are composed of numerous ciliated epithelial tubules called nephrons. Each
nephron functions to reabsorb nutrients and concentrate waste products into urine. Defects …

Cilia are microtubule‐based structures that either transmit information into the cell or move
fluid outside of the cell. There are many human diseases that arise from malfunctioning cilia …

The mammalian kidney develops in three sequential stages referred to as the pronephros,
mesonephros, and metanephros, each developing from the preceding form. All three phases …