Angiotensin II signal transduction: an update on mechanisms of physiology and pathophysiology
The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …
Mechanisms and physiological implications of cooperative gating of clustered ion channels
Ion channels play a central role in the regulation of nearly every cellular process. Dating
back to the classic 1952 Hodgkin–Huxley model of the generation of the action potential, ion …
back to the classic 1952 Hodgkin–Huxley model of the generation of the action potential, ion …
[HTML][HTML] Smooth muscle ion channels and regulation of vascular tone in resistance arteries and arterioles
NR Tykocki, EM Boerman… - Comprehensive Physiology, 2017 - ncbi.nlm.nih.gov
Vascular tone of resistance arteries and arterioles determines peripheral vascular
resistance, contributing to the regulation of blood pressure and blood flow to, and within the …
resistance, contributing to the regulation of blood pressure and blood flow to, and within the …
AKAP150-dependent cooperative TRPV4 channel gating is central to endothelium-dependent vasodilation and is disrupted in hypertension
Endothelial cell dysfunction, characterized by a diminished response to endothelial cell–
dependent vasodilators, is a hallmark of hypertension. TRPV4 channels play a major role in …
dependent vasodilators, is a hallmark of hypertension. TRPV4 channels play a major role in …
Novel Smooth Muscle Ca2+-Signaling Nanodomains in Blood Pressure Regulation
Background: Ca2+ signals in smooth muscle cells (SMCs) contribute to vascular resistance
and control blood pressure. Increased vascular resistance in hypertension has been …
and control blood pressure. Increased vascular resistance in hypertension has been …
Calcium channels in vascular smooth muscle
Abstract Calcium (Ca 2+) plays a central role in excitation, contraction, transcription, and
proliferation of vascular smooth muscle cells (VSMs). Precise regulation of intracellular Ca …
proliferation of vascular smooth muscle cells (VSMs). Precise regulation of intracellular Ca …
Inward rectifier potassium (Kir2. 1) channels as end‐stage boosters of endothelium‐dependent vasodilators
Key points Increase in endothelial cell (EC) calcium activates calcium‐sensitive intermediate
and small conductance potassium (IK and SK) channels, thereby causing hyperpolarization …
and small conductance potassium (IK and SK) channels, thereby causing hyperpolarization …
Ion channel remodeling in vascular smooth muscle during hypertension: Implications for novel therapeutic approaches
BK Joseph, KM Thakali, CL Moore, SW Rhee - Pharmacological research, 2013 - Elsevier
Ion channels are multimeric, transmembrane proteins that selectively mediate ion flux across
the plasma membrane in a variety of cells including vascular smooth muscle cells (VSMCs) …
the plasma membrane in a variety of cells including vascular smooth muscle cells (VSMCs) …
Cellular and molecular effects of hyperglycemia on ion channels in vascular smooth muscle
M Nieves-Cintrón, VA Flores-Tamez, T Le… - Cellular and Molecular …, 2021 - Springer
Diabetes affects millions of people worldwide. This devastating disease dramatically
increases the risk of developing cardiovascular disorders. A hallmark metabolic abnormality …
increases the risk of developing cardiovascular disorders. A hallmark metabolic abnormality …
Calcium signals that determine vascular resistance
M Ottolini, K Hong, SK Sonkusare - … Reviews: Systems Biology …, 2019 - Wiley Online Library
Small arteries in the body control vascular resistance, and therefore, blood pressure and
blood flow. Endothelial and smooth muscle cells in the arterial walls respond to various …
blood flow. Endothelial and smooth muscle cells in the arterial walls respond to various …