Genome-wide discovery of somatic coding and noncoding mutations in pediatric endemic and sporadic Burkitt lymphoma
Although generally curable with intensive chemotherapy in resource-rich settings, Burkitt
lymphoma (BL) remains a deadly disease in older patients and in sub-Saharan Africa …
lymphoma (BL) remains a deadly disease in older patients and in sub-Saharan Africa …
[HTML][HTML] miR-142: A Master Regulator in Hematological Malignancies and Therapeutic Opportunities
W Huang, D Paul, GA Calin, R Bayraktar - Cells, 2023 - mdpi.com
MicroRNAs (miRNAs) are a type of non-coding RNA whose dysregulation is frequently
associated with the onset and progression of human cancers. miR-142, an ultra-conserved …
associated with the onset and progression of human cancers. miR-142, an ultra-conserved …
[HTML][HTML] Consequences of genetic variants in miRNA genes
M Machowska, P Galka-Marciniak… - Computational and …, 2022 - Elsevier
MicroRNAs (miRNAs) are small non-coding RNAs that posttranscriptionally regulate the
expression of most genes. They are involved in regulating many physiological processes …
expression of most genes. They are involved in regulating many physiological processes …
[HTML][HTML] Genome-wide discovery of somatic regulatory variants in diffuse large B-cell lymphoma
Diffuse large B-cell lymphoma (DLBCL) is an aggressive cancer originating from mature B-
cells. Prognosis is strongly associated with molecular subgroup, although the driver …
cells. Prognosis is strongly associated with molecular subgroup, although the driver …
MIR142 Loss-of-Function Mutations Derepress ASH1L to Increase HOXA Gene Expression and Promote Leukemogenesis
Point mutations in the seed sequence of miR-142-3p are present in a subset of acute
myelogenous leukemia (AML) and in several subtypes of B-cell lymphoma. Here, we show …
myelogenous leukemia (AML) and in several subtypes of B-cell lymphoma. Here, we show …
[HTML][HTML] Somatic mutations in miRNA genes in lung cancer—potential functional consequences of non-coding sequence variants
P Galka-Marciniak, MO Urbanek-Trzeciak… - Cancers, 2019 - mdpi.com
A growing body of evidence indicates that miRNAs may either drive or suppress
oncogenesis. However, little is known about somatic mutations in miRNA genes. To …
oncogenesis. However, little is known about somatic mutations in miRNA genes. To …
[HTML][HTML] The miR-26b-5p/KPNA2 axis is an important regulator of Burkitt lymphoma cell growth
F Niu, M Kazimierska, IM Nolte, MM Terpstra… - Cancers, 2020 - mdpi.com
The expression of several microRNAs (miRNAs) is known to be changed in Burkitt
lymphoma (BL), compared to its normal counterparts. Although for some miRNAs, a role in …
lymphoma (BL), compared to its normal counterparts. Although for some miRNAs, a role in …
MicroRNAs as biomarkers of B-cell lymphoma
B-cell lymphomas represent a diverse group of neoplasms classified primarily by
histopatholgy and are often challenging to accurately diagnose. Despite having been …
histopatholgy and are often challenging to accurately diagnose. Despite having been …
[HTML][HTML] MiR-378a-3p is critical for Burkitt lymphoma cell growth
F Niu, A Dzikiewicz-Krawczyk, J Koerts, D de Jong… - Cancers, 2020 - mdpi.com
Simple Summary MicroRNAs (miRNAs) are small RNAs that regulate expression of specific
target genes. We observed elevated levels of miR-378a-3p in Burkitt lymphoma (BL) and …
target genes. We observed elevated levels of miR-378a-3p in Burkitt lymphoma (BL) and …
[HTML][HTML] Non-coding RNA editing in cancer pathogenesis
In the last two decades, RNA post-transcriptional modifications, including RNA editing, have
been the subject of increasing interest among the scientific community. The efforts of the …
been the subject of increasing interest among the scientific community. The efforts of the …