The aminoacyl-tRNA synthetases are an essential and universally distributed family of
enzymes that plays a critical role in protein synthesis, pairing tRNAs with their cognate …

Aminoacyl-tRNA synthetases (ARSs) are universal enzymes that catalyze the attachment of
amino acids to the 3′ ends of their cognate tRNAs. The resulting aminoacylated tRNAs are …

Proofreading (editing) of mischarged tRNAs by cytoplasmic aminoacyl-tRNA synthetases
(aaRSs), whose impairment causes neurodegeneration and cardiac diseases, is of high …

Errors are inherent in all biological systems. Errors in protein translation are particularly
frequent giving rise to a collection of protein quasi-species, the diversity of which will vary …

Aminoacyl-tRNA synthetases (aaRS) ensure the faithful transmission of genetic information
in all living cells. The 24 known aaRS families are divided into 2 structurally distinct classes …

Genetic code expansion for synthesis of proteins containing noncanonical amino acids is a
rapidly growing field in synthetic biology. Creating optimal orthogonal translation systems …

The translation of genes into functional proteins involves error. Mistranslation is a known
cause of disease, but, surprisingly, recent studies suggest that certain organisms from all …

Mistranslation broadly encompasses the introduction of errors during any step of protein
synthesis, leading to the incorporation of an amino acid that is different from the one …

Accurate translation of mRNA into protein is vital for maintenance of cellular integrity.
Translational fidelity is achieved by two key events: synthesis of correctly paired aminoacyl …

Mollicutes is a class of parasitic bacteria that have evolved from a common Firmicutes
ancestor mostly by massive genome reduction. With genomes under 1 Mbp in size, most …