Background: The American Heart Association, in conjunction with the National Institutes of
Health, annually reports the most up-to-date statistics related to heart disease, stroke, and …

The view that substance addiction is a brain disease, although widely accepted in the
neuroscience community, has become subject to acerbic criticism in recent years. These …

Behaviors and disorders related to self-regulation, such as substance use, antisocial
behavior and attention-deficit/hyperactivity disorder, are collectively referred to as …

Background Variation in liability to cannabis use disorder has a strong genetic component
(estimated twin and family heritability about 50–70%) and is associated with negative …

We conducted genome-wide association analyses of over 250,000 participants of European
(EUR) and African (AFR) ancestry from the Million Veteran Program using electronic health …

Problematic alcohol use (PAU) is a leading cause of death and disability worldwide.
Although genome-wide association studies have identified PAU risk genes, the genetic …

Admixed populations are routinely excluded from genomic studies due to concerns over
population structure. Here, we present a statistical framework and software package, Tractor …

Human brain structure changes throughout the lifespan. Altered brain growth or rates of
decline are implicated in a vast range of psychiatric, developmental and neurodegenerative …

Alcohol consumption level and alcohol use disorder (AUD) diagnosis are moderately
heritable traits. We conduct genome-wide association studies of these traits using …

Genome-wide association studies (GWASs) have focused primarily on populations of
European descent, but it is essential that diverse populations become better represented …