Recombinant proteins are becoming increasingly important for industrial applications, where
Escherichia coli is the most widely used bacterial host for their production. However, the …

Intracellular accumulation of altered and misfolded proteins is the basis of most
neurodegenerative disorders. Altered proteins are usually organised in the form of toxic …

Cytoplasmic α-synuclein (α-syn) aggregates, referred to as Lewy bodies, are pathological
hallmarks of a number of neurodegenerative diseases, most notably Parkinson disease …

Thermal aggregation of bovine serum albumin (BSA) has been studied using dynamic light
scattering, asymmetric flow field-flow fractionation and analytical ultracentrifugation. The …

Curcumin has a wide range of pharmacological activities, but its poor water solubility,
chemical instability, and low bioavailability extensively limit the further application in food …

Cells maintain a healthy proteome through continuous evaluation of the quality of each of
their proteins. Quality control requires the coordinated action of chaperones and proteolytic …

Autophagy is a vital lysosomal degradation and recycling pathway in the eukaryotic cell,
responsible for maintaining an intricate balance between cell survival and cell death …

Autophagy fights against harmful stimuli and degrades cytosolic macromolecules,
organelles, and intracellular pathogens. Autophagy dysfunction is associated with many …

Pontin (RUVBL1, TIP49, TIP49a, Rvb1) and Reptin (RUVBL2, TIP48, TIP49b, Rvb2) are
highly conserved ATPases of the AAA+ (ATPases Associated with various cellular Activities) …

Proteins are central to life functions. Alterations in the structure of proteins are reflected in
their function. Misfolded proteins and their aggregates present a significant risk to the cell …