Fifty years since the first description of an association between HLA and human disease,
HLA molecules have proven to be central to physiology, protective immunity and …

Abstract Autoimmune Syndrome Induced by Adjuvant (ASIA) is a definition aimed to
describe the common etiological process at the root of five clinical entities sharing similar …

Abstract The analysis of Adverse Events Following Immunization (AEFI) is important in a
balanced epidemiological evaluation of vaccines and in the issues related to vaccine injury …

Background The incidence of narcolepsy rose sharply after the swine influenza A (H1N1)
vaccination campaign with Pandemrix. Narcolepsy is an immune-related disorder with …

In the wake of the A/California/7/2009 H1N1 influenza pandemic vaccination campaigns in
2009-2010, an increased incidence of the chronic sleep-wake disorder narcolepsy was …

Abstract Narcolepsy type 1 (NT1) is caused by a loss of hypocretin/orexin transmission. Risk
factors include pandemic 2009 H1N1 influenza A infection and immunization with …

Background Neuropathological findings support an autoimmune etiology as an underlying
factor for loss of orexin-producing neurons in spontaneous narcolepsy type 1 (narcolepsy …

Vaccines protect against many infectious diseases, including some that can directly or
indirectly cause nervous system damage. Serious neurological consequences of …

The central hypersomnias encompass a range of conditions causing persisting or
intermittent excessive daytime sleepiness (EDS). These conditions therefore present not …

Narcolepsy type 1 is characterised by an increase in body weight after disease onset,
frequently leading to obesity. It was suggested that this weight gain may be counteracted by …