Antimicrobial resistance constitutes one of the major challenges facing humanity in the
Twenty-First century. The spread of resistant pathogens has been such that the possibility of …

In this review, a general introduction to fragment-based drug design and the underlying
concepts is given. General considerations and methodologies ranging from library …

Biofilm formation significantly contributes to microbial survival in hostile environments and it
is currently considered a key virulence factor for pathogens responsible for serious chronic …

The survival selection pressure caused by antibiotic-mediated bactericidal and bacteriostatic
activity is one of the important inducements for bacteria to develop drug resistance. Bacteria …

Antimicrobial resistance (AMR) is a serious threat to public health globally, manifested by
the frequent emergence of multidrug resistant pathogens that render current chemotherapy …

Quorum sensing (QS) is a process of bacterial communication that involves the use of
biochemical signals and adjusts the expression of specific genes as a response to the …

Quorum sensing (QS) is a widespread intercellular form of communication to coordinate
physiological processes and cooperative activities of bacteria at the population level, and it …

Bacteria can utilize chemical signals to coordinate the expression of group-beneficial
behaviors in a method of cell–cell communication called quorum sensing (QS). The …

Covering: 2016 to 2022 RNA polymerase (RNAP) is the central enzyme in bacterial gene
expression representing an attractive and validated target for antibiotics. Two well-known …

The Gram-negative opportunistic pathogen Pseudomonas aeruginosa causes severe
nosocomial infections. It uses quorum sensing (QS) to regulate and coordinate population …