Adipose tissue is the largest endocrine organ and an accepted contributor to overall energy
homeostasis. There is strong evidence linking increased adiposity to the development of 13 …

Long-term exposure to excess estrogen increases the risk of breast cancer and type 1
endometrial cancer. Most of the estrogen in premenopausal women is synthesized by the …

Aromatase is the enzyme that catalyzes the conversion of androgens to estrogens. Initial
studies of its enzymatic activity and function took place in an environment focused on …

Abstract The cytochrome P450 (P450) enzymes first attracted interest because of their
relevance to the metabolism of drugs, steroids, and carcinogens. Collectively, the 57 human …

▪ Abstract The metabolic nuclear receptors act as metabolic and toxicological sensors,
enabling the organism to quickly adapt to environmental changes by inducing the …

The liver receptor homolog-1 (LRH-1; NR5A2) and steroidogenic factor-1 (SF-1; NR5A1) are
two orphan members of the Ftz-F1 subfamily of nuclear receptors. LRH-1 is expressed in …

Estrogens are synthesized by the aromatase enzyme encoded by the Cyp19a1 gene, which
contains an unusually large regulatory region. In most mammals, aromatase expression is …

Obesity has been associated with abnormally high expression of the enzyme aromatase in
the breast, increased local estrogen production, and predisposition to breast hyperplasia …

One in eight women will develop breast cancer over their lifetime making it the most
common female cancer. The cause of breast cancer is multifactorial and includes hormonal …

Much of P450 research has always been done with the view of appUcation to humans, even
when done with experimental animals and microorganisms. Research with the human …