[HTML][HTML] Promising strategy of mPTP modulation in cancer therapy: an emerging progress and future insight

M Waseem, BD Wang - International Journal of Molecular Sciences, 2023 - mdpi.com
Cancer has been progressively a major global health concern. With this developing global
concern, cancer determent is one of the most significant public health challenges of this era …

[HTML][HTML] Role of the dietary phytochemical curcumin in targeting cancer cell signalling pathways

AP Mishra, Swetanshu, P Singh, S Yadav, M Nigam… - Plants, 2023 - mdpi.com
The diarylheptanoid curcumin [(1 E, 6 E)-1, 7-bis (4-hydroxy-3-methoxyphenyl) hepta-1, 6-
diene-3, 5-dione] is one of the phenolic pigments responsible for the yellow colour of …

[HTML][HTML] Phenolic phytochemicals for prevention and treatment of colorectal cancer: A critical evaluation of in vivo studies

S De, S Paul, A Manna, C Majumder, K Pal, N Casarcia… - Cancers, 2023 - mdpi.com
Simple Summary Colorectal cancer (CRC) is a significant cause of death worldwide. The
inefficacy of the current treatment regimens is reflected in the frequent recurrence and …

[HTML][HTML] Resveratrol, epigallocatechin gallate and curcumin for cancer therapy: challenges from their pro-apoptotic properties

A Chimento, M D'Amico, A De Luca, FL Conforti… - Life, 2023 - mdpi.com
Plant-derived bioactive compounds are gaining wide attention for their multiple health-
promoting activities and in particular for their anti-cancer properties. Several studies have …

[HTML][HTML] Potential of synthetic and natural compounds as novel histone deacetylase inhibitors for the treatment of hematological malignancies

D Pal, K Raj, SS Nandi, S Sinha, A Mishra, A Mondal… - Cancers, 2023 - mdpi.com
Simple Summary Histone deacetylases (HDACs) are epigenetic regulators that influence
chromatin structure and gene transcription, but also the function of non-histone targets like …

Modulation of hypoxia-inducible factor-1 signaling pathways in cancer angiogenesis, invasion, and metastasis by natural compounds: a comprehensive and critical …

S Fakhri, SZ Moradi, F Faraji, L Kooshki… - Cancer and Metastasis …, 2024 - Springer
Tumor cells employ multiple signaling mediators to escape the hypoxic condition and trigger
angiogenesis and metastasis. As a critical orchestrate of tumorigenic conditions, hypoxia …

[HTML][HTML] Curcuminoids as Anticancer Drugs: Pleiotropic Effects, Potential for Metabolic Reprogramming and Prospects for the Future

DL Pouliquen, KG Trošelj, RJ Anto - Pharmaceutics, 2023 - mdpi.com
The number of published studies on curcuminoids in cancer research, including its lead
molecule curcumin and synthetic analogs, has been increasing substantially during the past …

Current advances in nanoformulations of therapeutic agents targeting tumor microenvironment to overcome drug resistance

S Fakhri, SZ Moradi, F Faraji, T Farhadi… - Cancer and Metastasis …, 2023 - Springer
The tumor microenvironment (TME) plays a pivotal role in cancer development and
progression. In this line, revealing the precise mechanisms of the TME and associated …

Phytochemicals for the prevention and treatment of pancreatic cancer: Current progress and future prospects

N Casarcia, P Rogers, E Guld, S Iyer… - British Journal of …, 2023 - Wiley Online Library
Pancreatic cancer is the third leading cause of cancer‐related deaths in the United States,
owing to its aggressive nature and suboptimal treatment options, emphasizing the need for …

Signaling pathways driving ocular malignancies and their targeting by bioactive phytochemicals

CR Croley, J Pumarol, BE Delgadillo, AC Cook… - Pharmacology & …, 2023 - Elsevier
Ocular cancers represent a rare pathology. The American Cancer Society estimates that
3,360 cases of ocular cancer occur annually in the United States. The major types of cancers …