Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a natural
product class that has undergone significant expansion due to the rapid growth in genome …

Pseudomonas aeruginosa is an opportunistic pathogen affecting immunocompromised
patients. It is known as the leading cause of morbidity and mortality in cystic fibrosis (CF) …

Notably, bacterial biofilm formation is increasingly recognized as a passive virulence factor
facilitating many infectious disease processes. In this review we will focus on bacterial …

The ability to construct and maintain a structured multicellular bacterial community depends
critically on the production of extracellular matrix components (1, 2). While the biofilm matrix …

Microbial communities enmeshed in a matrix of macromolecules, termed as biofilms, are the
natural setting of bacteria. Exopolysaccharide is a critical matrix component of biofilms …

The excessive consumption of fossil fuels causes massive emission of CO2, leading to
climate deterioration and environmental pollution. The development of substitutes and …

Twenty-five years have passed since the discovery of cyclic dimeric (3′→ 5′) GMP (cyclic
di-GMP or c-di-GMP). From the relative obscurity of an allosteric activator of a bacterial …

P. aeruginosa is an opportunistic pathogenic bacterium responsible for both acute and
chronic infections. Beyond its natural resistance to many drugs, its ability to form biofilm, a …

Extracellular polysaccharides comprise a major component of the biofilm matrix. Many
species that are adept at biofilm formation have the capacity to produce multiple types of …

Biofilms are communities of microorganisms embedded in extracellular polymeric
substances (EPS) matrix. Bacteria in biofilms demonstrate distinct features from their free …