Asthma and chronic obstructive pulmonary disease are inflammatory lung disorders
responsible for significant morbidity and mortality worldwide. While the importance of …

The inhibitor of nuclear factor‐κB (IκB) kinase (IKK) complex is the master regulator of the NF‐
κB signaling pathway. The activation of the IKK complex is a tightly regulated, highly …

The cystic fibrosis (CF) airway bacterial pathogen Pseudomonas aeruginosa secretes
multiple virulence factors. Among these, the redox active exotoxin pyocyanin (PCN) is …

Muscle development, growth, and maintenance require an intricate and timely series of
events initiated through a multitude of signaling pathways. The very nature of skeletal …

A wealth of recent studies points to the importance of airway epithelial cells in the
orchestration of inflammatory responses in the allergic inflamed lung. Studies also point to a …

Rationale: Epigenetic changes to airway cells have been proposed as important modulators
of the effects of environmental exposures on airway diseases, yet no study to date has …

Context.—Idiopathic pulmonary fibrosis is a uniformly lethal disease with limited biomarkers
and no proven therapeutic intervention short of lung transplantation. Pulmonary fibrosis at …

Parental, particularly maternal, smoking increases the risk for childhood allergic asthma and
infection. Similarly, in a murine allergic asthma model, prenatal plus early postnatal …

Introduction: NF-κB is a key regulator of inflammation and immunity in cancer development.
The IκB kinase (IKK) is a multisubunit complex containing catalytic subunits termed IKK-α,-β …

Deterioration of diaphragm function is one of the prominent factors that contributes to the
susceptibility of serious respiratory infections and development of respiratory failure in …