Notch signaling is an evolutionarily highly conserved signaling mechanism, but in contrast to
signaling pathways such as Wnt, Sonic Hedgehog, and BMP/TGF-β, Notch signaling occurs …

Zebrafish (Danio rerio) has been a prominent model vertebrate in a variety of biological
disciplines. Substantial information gathered from developmental and genetic research …

In this study we describe a model system that allows continuous in vivo observation of the
vertebrate embryonic vasculature. We find that the zebrafish fli1 promoter is able to drive …

In a large-scale screen, we isolated mutants displaying a specific visible phenotype in
embryos or early larvae of the zebrafish, Danio rerio. Males were mutagenized with …

The zebrafish has become one of the most important model organisms to study biologial
processes in vivo. As a vertebrate that has many of the strengths of invertebrate model …

Nuclear proteins are often given a concise title that captures their function, such as
'transcription factor,''polymerase'or 'nuclear-receptor.'However, for members of the …

Recent evidence indicates that acquisition of artery or vein identity during vascular
development is governed, in part, by genetic mechanisms. The artery-specific expression of …

The appearance of molecular differences between arterial and venous endothelial cells
before circulation suggests that genetic factors determine these cell types. We find that …

Lateral inhibition, mediated by Notch signaling, leads to the selection of cells that are
permitted to become neurons within domains defined by proneural gene expression …

Adult neurogenesis is a widespread trait of vertebrates; however, the degree of this ability
and the underlying activity of the adult neural stem cells differ vastly among species. In …