Growth inhibitory signaling of the Raf/MEK/ERK pathway
PK Wu, A Becker, JI Park - International journal of molecular sciences, 2020 - mdpi.com
In response to extracellular stimuli, the Raf/MEK/extracellular signal-regulated kinase (ERK)
pathway regulates diverse cellular processes. While mainly known as a mitogenic signaling …
pathway regulates diverse cellular processes. While mainly known as a mitogenic signaling …
HSP70 family in cancer: signaling mechanisms and therapeutic advances
K Zhao, G Zhou, Y Liu, J Zhang, Y Chen, L Liu… - Biomolecules, 2023 - mdpi.com
The 70 kDa heat shock proteins (HSP70s) are a group of highly conserved and inducible
heat shock proteins. One of the main functions of HSP70s is to act as molecular chaperones …
heat shock proteins. One of the main functions of HSP70s is to act as molecular chaperones …
Similarities and differences of Hsp70, hsc70, Grp78 and mortalin as cancer biomarkers and drug targets
Abstract Background: Upregulation of Heath Shock Protein 70 (HSP70) chaperones
supports cancer cell survival. Their high homology causes a challenge to differentiate them …
supports cancer cell survival. Their high homology causes a challenge to differentiate them …
A bird's eye view of mitochondrial unfolded protein response in cancer: mechanisms, progression and further applications
X Zhang, Y Fan, K Tan - Cell Death & Disease, 2024 - nature.com
Mitochondria are essential organelles that play critical roles in energy metabolism,
apoptosis and various cellular processes. Accumulating evidence suggests that …
apoptosis and various cellular processes. Accumulating evidence suggests that …
Mortalin (GRP75/HSPA9) promotes survival and proliferation of thyroid carcinoma cells
We previously reported that upregulation of mortalin (HSPA9/GRP75), the mitochondrial
HSP70 chaperone, facilitates tumor cell proliferation and survival in human medullary …
HSP70 chaperone, facilitates tumor cell proliferation and survival in human medullary …
Targeting ribosome biogenesis reinforces ERK-dependent senescence in pancreatic cancer
MC Rowell, X Deschenes-Simard, S Lopes-Paciencia… - Cell Cycle, 2023 - Taylor & Francis
Pancreatic adenocarcinomas (PDAC) often possess mutations in K-Ras that stimulate the
ERK pathway. Aberrantly high ERK activation triggers oncogene-induced senescence …
ERK pathway. Aberrantly high ERK activation triggers oncogene-induced senescence …
Mortalin (HSPA9) facilitates BRAF-mutant tumor cell survival by suppressing ANT3-mediated mitochondrial membrane permeability
Mortalin [also known as heat shock protein family A (HSP70) member 9 (HSPA9) or glucose-
regulated protein 75 (GRP75)] is a mitochondrial molecular chaperone that is often up …
regulated protein 75 (GRP75)] is a mitochondrial molecular chaperone that is often up …
Mortalin/HSPA9 targeting selectively induces KRAS tumor cell death by perturbing mitochondrial membrane permeability
The mitochondrial HSP70 chaperone mortalin (HSPA9/GRP75) is often upregulated and
mislocalized in MEK/ERK-deregulated tumors. Here, we show that mortalin depletion can …
mislocalized in MEK/ERK-deregulated tumors. Here, we show that mortalin depletion can …
HSPA9/Mortalin mediates axo-protection and modulates mitochondrial dynamics in neurons
CA Ferré, A Thouard, A Bétourné, AL Le Dorze… - Scientific reports, 2021 - nature.com
Mortalin is a mitochondrial chaperone protein involved in quality control of proteins imported
into the mitochondrial matrix, which was recently described as a sensor of neuronal stress …
into the mitochondrial matrix, which was recently described as a sensor of neuronal stress …
Mortalin depletion induces MEK/ERK-dependent and ANT/CypD-mediated death in vemurafenib-resistant B-RafV600E melanoma cells
Therapy resistance to a selective B-Raf inhibitor (BRAFi) poses a challenge in treating
patients with BRAF-mutant melanomas. Here, we report that RNA interference of mortalin …
patients with BRAF-mutant melanomas. Here, we report that RNA interference of mortalin …