Furin is an important mammalian proprotein convertase that catalyzes the proteolytic
maturation of a variety of prohormones and proproteins in the secretory pathway. In the …

Brain-derived neurotrophic factor (BDNF) is involved in pathophysiological mechanisms in
neuropsychiatric diseases, including depression, anxiety, and schizophrenia (SZ), as well as …

Major depression (MD) is one of the most common psychiatric disorders worldwide.
Currently, the first-line treatment for MD targets the serotonin system but these drugs, notably …

Mood disorders are associated with hypothalamic-pituitary-adrenal axis overactivity
resulting from a decreased inhibitory feedback exerted by the hippocampus on this brain …

Severe stress is among the most robust risk factors for the development of psychiatric
disorders. Imaging studies indicate that life stress is integral to shaping the human brain …

Neuropsychiatric conditions represent a major medical and societal challenge. The etiology
of these conditions is very complex and combines genetic and environmental factors. The …

Schizophrenia is a severe neuropsychiatric disorder, and its etiology remains largely
unknown. Environmental factors have been reported to play roles in the pathogenesis of …

The present study aims to emphasize the enhanced efficacy of long acting in-situ gel forming
implants (ISGFI) based on poly (lactic-co-glycolic acid)(PLGA) matrix to deliver anti …

Abstract Background Matrix metalloproteinase 9 (MMP-9), an extracellular network protease
implicated in glutamatergic signaling, may be part of the pathophysiology of schizophrenia …

Stress is proposed to be a crucial factor in the onset and presentation of psychosis. The
early stage of psychosis provides a window into how stress interacts with the emergence of …