Lessons Learned for Pathogenesis, Immunology, and Disease of Erythrocytic Parasites: Plasmodium and Babesia

V Djokic, SC Rocha, N Parveen - Frontiers in cellular and infection …, 2021 - frontiersin.org
Malaria caused by Plasmodium species and transmitted by Anopheles mosquitoes affects
large human populations, while Ixodes ticks transmit Babesia species and cause …

[HTML][HTML] The interleukin-10 family: major regulators of the immune response against Plasmodium falciparum infections

KOA Abosalif, AE Abdalla, K Junaid, LB Eltayeb… - Saudi Journal of …, 2023 - Elsevier
Malaria caused by the Plasmodium falciparum strain is more severe because of this
protozoan's ability to disrupt the physiology of host cells during the blood stages of …

What Is Known about the Immune Response Induced by Plasmodium vivax Malaria Vaccine Candidates?

C López, Y Yepes-Pérez, N Hincapié-Escobar… - Frontiers in …, 2017 - frontiersin.org
Malaria caused by Plasmodium vivax continues being one of the most important infectious
diseases around the world; P. vivax is the second most prevalent species and has the …

Malaria-specific Type 1 regulatory T cells are more abundant in first pregnancies and associated with placental malaria

AS Kirosingh, A Delmastro, A Kakuru… - Ebiomedicine, 2023 - thelancet.com
Background Malaria in pregnancy (MIP) causes higher morbidity in primigravid compared to
multigravid women; however, the correlates and mechanisms underlying this gravidity …

Extrafollicular CD4 T cell-derived IL-10 functions rapidly and transiently to support anti-Plasmodium humoral immunity

FA Surette, JJ Guthmiller, L Li, AJ Sturtz, R Vijay… - PLoS …, 2021 - journals.plos.org
Immunity against malaria depends on germinal center (GC)-derived antibody responses that
are orchestrated by T follicular helper (TFH) cells. Emerging data show that the regulatory …

The impact of malaria parasites on dendritic cell–T cell interaction

RS Osii, TD Otto, P Garside, FM Ndungu… - Frontiers in …, 2020 - frontiersin.org
Malaria is caused by apicomplexan parasites of the genus Plasmodium. While infection
continues to pose a risk for the majority of the global population, the burden of disease …

Mouse models for unravelling immunology of blood stage malaria

AC Olatunde, DH Cornwall, M Roedel, TJ Lamb - Vaccines, 2022 - mdpi.com
Malaria comprises a spectrum of disease syndromes and the immune system is a major
participant in malarial disease. This is particularly true in relation to the immune responses …

Bhlhe40 limits early IL-10 production from CD4+ T cells during Plasmodium yoelii 17X infection

KA O'Neal, SL Zeltner, CL Foscue… - Infection and …, 2023 - Am Soc Microbiol
The cytokine IL-10 suppresses T-cell-mediated immunity, which is required to control
infection with Plasmodium yoelii. Consequently, IL-10 can delay the time needed to resolve …

Profiling MHC II immunopeptidome of blood‐stage malaria reveals that cDC 1 control the functionality of parasite‐specific CD 4 T cells

M Draheim, MF Wlodarczyk, K Crozat… - EMBO molecular …, 2017 - embopress.org
In malaria, CD 4 Th1 and T follicular helper (TFH) cells are important for controlling parasite
growth, but Th1 cells also contribute to immunopathology. Moreover, various regulatory CD …

Overview of LAG-3-expressing, IL-10-producing regulatory T cells

K Fujio, K Yamamoto, T Okamura - Emerging Concepts Targeting Immune …, 2017 - Springer
Regulatory T cells (Treg cells) play crucial roles in the induction of peripheral tolerance to
self-and foreign-antigens. IL-10-producing regulatory T cells (IL-10-producing Treg cells) …