Our understanding of the ubiquitin code has greatly evolved from conventional E1, E2 and
E3 enzymes that modify Lys residues on specific substrates with a single type of ubiquitin …

The ubiquitin system has become synonymous with the modification of lysine residues.
However, the substrate scope and diversity of the conjugation machinery have been …

Acute lysosomal membrane damage reduces the cellular population of functional
lysosomes. However, these damaged lysosomes have a remarkable recovery potential …

The endoplasmic reticulum (ER) is a hotspot for many essential cellular functions. The ER
membrane is highly dynamic, which affects many cellular processes that take place within …

Ubiquitination is a posttranslational modification that regulates a multitude of cellular
functions. Pathogens, such as bacteria and viruses, have evolved sophisticated …

Acinetobacter baumannii is a highly antibiotic resistant Gram-negative bacterium that
causes life-threatening infections in humans with a very high mortality rate. A. baumannii is …

The post-translational modification of proteins with ubiquitin plays a central role in nearly all
aspects of eukaryotic biology. Historically, studies have focused on the conjugation of …

The covalent attachment of ubiquitin is a common regulatory mechanism in various proteins.
Although it has long been thought that the substrates of ubiquitination are limited to proteins …

We describe the development and optimization of a methodology to prepare peptides and
proteins modified on the arginine residue with an adenosine-di-phosphate-ribosyl (ADPr) …

Legionella pneumophila grows intracellularly within the membrane-bound Legionella-
containing vacuole (LCV) established by proteins translocated via the bacterial type IV …