Mitogen-activated protein kinases (MAPKs) mediate a wide variety of cellular behaviors in
response to extracellular stimuli. One of the main subgroups, the p38 MAP kinases, has …

Jun N-terminal kinases or JNKs play a critical role in death receptor-initiated extrinsic as well
as mitochondrial intrinsic apoptotic pathways. JNKs activate apoptotic signaling by the …

In addition to inducing new transcriptional activities that lead within a few hours to the
accumulation of heat shock proteins (Hsps), heat shock activates within minutes the major …

Cells are continuously exposed to a variety of environmental stresses and have to decide 'to
be or not to be'depending on the types and strength of stress. Among the many signaling …

Cell death is an essential phenomenon in normal development and homeostasis, but also
plays a crucial role in various pathologies. Our understanding of the molecular mechanisms …

Intracellular MAPK (mitogen-activated protein kinase) signalling cascades probably play an
important role in the pathogenesis of cardiac and vascular disease. A substantial amount of …

The Akt family of serine/threonine-directed kinases promotes cellular survival in part by
phosphorylating and inhibiting death-inducing proteins. Here we describe a novel functional …

Anticancer treatment using cytotoxic drugs is considered to mediate cell death by activating
key elements of the apoptosis program and the cellular stress response. While proteolytic …

Over the past decade, the identification of cancer-associated factors has been a subject of
primary interest not only for understanding the basic mechanisms of tumorigenesis but also …

Germ cells are sensitive to genotoxins, and ovarian failure and infertility are major side
effects of chemotherapy in young patients with cancer. Here we describe the c-Abl–TAp63 …