Hepatocellular carcinoma (HCC) remains one of the most prevalent and deadliest cancers.
The poor outcome associated with HCC is dramatically changing due to the advent of …

Hepatocytes are the main workers in the hepatic factory, managing metabolism of nutrients
and xenobiotics, production and recycling of proteins, and glucose and lipid homeostasis …

The liver carries a remarkable ability to regenerate rapidly after acute zonal damage. Single-
cell approaches are necessary to study this process, given the spatial heterogeneity of liver …

The concept of hepatocyte functional zonation is well established, with differences in
metabolism and xenobiotic processing determined by multiple factors including oxygen and …

In the mammalian liver, hepatocytes exhibit diverse metabolic and functional profiles based
on their location within the liver lobule. However, it is unclear whether this spatial variation …

Hepatocytes, the liver's predominant cells, perform numerous essential biological functions.
However, crucial events and regulators during hepatocyte maturation require in-depth …

The liver has a critical role in regulating host metabolism, immunity, detoxification, and
homeostasis. Proper liver function is essential for host health, and dysregulation of hepatic …

Cholestatic liver injuries, characterized by regional damage around the bile ductular region,
lack curative therapies and cause considerable mortality. Here we generated a high …

Abstract RNF43/ZNRF3 negatively regulate WNT signalling. Both genes are mutated in
several types of cancers, however, their contribution to liver disease is unknown. Here we …

The liver is known as an organ with high proliferation potential. Clarifying the cellular origin
and deepening the understanding of liver regeneration mechanisms will help provide new …