Airway remodeling in asthma

KP Hough, ML Curtiss, TJ Blain, RM Liu, J Trevor… - Frontiers in …, 2020 - frontiersin.org
Asthma is an inflammatory disease of the airways that may result from exposure to allergens
or other environmental irritants, resulting in bronchoconstriction, wheezing, and shortness of …

Early-life origins of chronic obstructive pulmonary disease

FD Martinez - New England Journal of Medicine, 2016 - Mass Medical Soc
Early-Life Origins of Chronic Obstructive Pulmonary Disease | New England Journal of Medicine
Skip to main content The New England Journal of Medicine homepage Advanced Search …

Burden of asthma and chronic obstructive pulmonary disease and access to essential medicines in low-income and middle-income countries

D Beran, HJ Zar, C Perrin, AM Menezes… - The Lancet Respiratory …, 2015 - thelancet.com
Demographic and epidemiological transitions are changing the age structure of the
population and the most common diseases. Non-communicable respiratory diseases are an …

Personalized medicine for patients with COPD: where are we?

FME Franssen, P Alter, N Bar… - … journal of chronic …, 2019 - Taylor & Francis
Chronic airflow limitation is the common denominator of patients with chronic obstructive
pulmonary disease (COPD). However, it is not possible to predict morbidity and mortality of …

Early origins of chronic obstructive pulmonary disease: prenatal and early life risk factors

M Deolmi, NM Decarolis, M Motta, H Makrinioti… - International Journal of …, 2023 - mdpi.com
The main risk factor for chronic obstructive pulmonary disease (COPD) is active smoking.
However, a considerable amount of people with COPD never smoked, and increasing …

The etiologic origins for chronic obstructive pulmonary disease

X Huang, X Mu, L Deng, A Fu, E Pu… - International journal of …, 2019 - Taylor & Francis
COPD, characterized by long-term poorly irreversible airway limitation and persistent
respiratory symptoms, has resulted in enormous challenges to human health worldwide …

Whole genome sequence analysis of pulmonary function and COPD in 19,996 multi-ethnic participants

X Zhao, D Qiao, C Yang, S Kasela, W Kim, Y Ma… - Nature …, 2020 - nature.com
Chronic obstructive pulmonary disease (COPD), diagnosed by reduced lung function, is a
leading cause of morbidity and mortality. We performed whole genome sequence (WGS) …

Identification of promising mutants associated with egg production traits revealed by genome-wide association study

J Yuan, C Sun, T Dou, G Yi, LJ Qu, L Qu, K Wang… - PLoS …, 2015 - journals.plos.org
Egg number (EN), egg laying rate (LR) and age at first egg (AFE) are important production
traits related to egg production in poultry industry. To better understand the knowledge of …

A genome-wide association study identifies distinct variants associated with pulmonary function among European and African ancestries from the UK Biobank

M Sinkala, SSM Elsheikh, M Mbiyavanga… - Communications …, 2023 - nature.com
Pulmonary function is an indicator of well-being, and pulmonary pathologies are the third
major cause of death worldwide. We analysed the UK Biobank genome-wide association …

Multi-omic association study identifies DNA methylation-mediated genotype and smoking exposure effects on lung function in children living in urban settings

M Dapas, EE Thompson, W Wentworth-Sheilds… - PLoS …, 2023 - journals.plos.org
Impaired lung function in early life is associated with the subsequent development of chronic
respiratory disease. Most genetic associations with lung function have been identified in …