Parvalbumin is a calcium-binding protein present in inhibitory interneurons that play an
essential role in regulating many physiological processes, such as intracellular signaling …

The intercalated disk is a cardiac specific structure composed of three main protein
complexes—adherens junctions, desmosomes, and gap junctions—that work in concert to …

The binding of calcium ions (Ca2+) to the calcium-binding proteins (CBPs) controls a
plethora of regulatory processes. Among the roles played by CBPs in several diseases, the …

Abstract Structure and functions of S100 proteins are regulated by two distinct calcium
binding EF hand motifs. In this work, we used solution‐state NMR spectroscopy to …

Mechanosensitive channel of large conductance (MscL) detects and responds to changes in
the pressure profile of cellular membranes and transduces the mechanical energy into …

A modification of the original Grand Canonical Monte Carlo (GCMC) method to handle
Donnan equilibrium is proposed that provides an equilibrium between two implicit-solvent …

Calmodulin (CaM) serves as an important Ca2+ signaling hub that regulates many protein
signaling pathways. Recently, it was demonstrated that plant CaM homologues can regulate …

We present simulation results for the Donnan equilibrium between a homogeneous bulk
reservoir and inhomogeneous confining geometries with varying number of restricted …

Congenital long QT syndrome (LQTS) is characterized by a prolonged QT-interval on an
electrocardiogram (ECG). An abnormal prolongation in the QT-interval increases the risk for …

Proton-coupled oligopeptide transporters (POTs) use the proton electrochemical gradient to
transport peptides across the cell membrane. Despite the significant biological and …