Reward signals in the cerebellum: origins, targets, and functional implications

D Kostadinov, M Häusser - Neuron, 2022 - cell.com
The cerebellum has long been proposed to play a role in cognitive function, although this
has remained controversial. This idea has received renewed support with the recent …

Computational principles of supervised learning in the cerebellum

JL Raymond, JF Medina - Annual review of neuroscience, 2018 - annualreviews.org
Supervised learning plays a key role in the operation of many biological and artificial neural
networks. Analysis of the computations underlying supervised learning is facilitated by the …

Bidirectional learning in upbound and downbound microzones of the cerebellum

CI De Zeeuw - Nature Reviews Neuroscience, 2021 - nature.com
Over the past several decades, theories about cerebellar learning have evolved. A relatively
simple view that highlighted the contribution of one major form of heterosynaptic plasticity to …

Prediction signals in the cerebellum: beyond supervised motor learning

C Hull - elife, 2020 - elifesciences.org
While classical views of cerebellar learning have suggested that this structure predominantly
operates according to an error-based supervised learning rule to refine movements …

Diverse inhibitory projections from the cerebellar interposed nucleus

EN Judd, SM Lewis, AL Person - Elife, 2021 - elifesciences.org
The cerebellum consists of parallel circuit modules that contribute to diverse behaviors,
spanning motor to cognitive. Recent work employing cell-type-specific tracing has identified …

Heterogeneous encoding of temporal stimuli in the cerebellar cortex

CI De Zeeuw, J Koppen, GG Bregman… - Nature …, 2023 - nature.com
Local feedforward and recurrent connectivity are rife in the frontal areas of the cerebral
cortex, which gives rise to rich heterogeneous dynamics observed in such areas. Recently …

Cerebellum encodes and influences the initiation, performance, and termination of discontinuous movements in mice

MA Gaffield, BA Sauerbrei, JM Christie - Elife, 2022 - elifesciences.org
The cerebellum is hypothesized to represent timing information important for organizing
salient motor events during periodically performed discontinuous movements. To provide …

Cerebellar plasticity and associative memories are controlled by perineuronal nets

D Carulli, R Broersen, F de Winter… - Proceedings of the …, 2020 - National Acad Sciences
Perineuronal nets (PNNs) are assemblies of extracellular matrix molecules, which surround
the cell body and dendrites of many types of neuron and regulate neural plasticity. PNNs are …

Dynamic changes in local activity and network interactions among the anterior cingulate, amygdala, and cerebellum during associative learning

HE Halverson, J Kim, JH Freeman - Journal of Neuroscience, 2023 - Soc Neuroscience
Communication between the cerebellum and forebrain structures is necessary for motor
learning and has been implicated in a variety of cognitive functions. The exact nature of …

SK2 channels in cerebellar Purkinje cells contribute to excitability modulation in motor-learning–specific memory traces

G Grasselli, HJ Boele, HK Titley, N Bradford… - PLoS …, 2020 - journals.plos.org
Neurons store information by changing synaptic input weights. In addition, they can adjust
their membrane excitability to alter spike output. Here, we demonstrate a role of such …