Background There is a rising prevalence of multimorbidity, particularly in older patients, and
a need for evidence-based medicines management interventions for this population. The …

Abstract Introduction The SPPiRE cluster randomized controlled trial found that a general
practitioner (GP)‐delivered medication review that incorporated screening for potentially …

Background Older patients with multimorbidity are under-represented in experimental
research. Objective To explore the barriers and facilitators to general practitioner (GP) and …

Multimorbidity (MM) is a widespread problem and it poses unsolved issues like the
healthcare professionals' training. A training curriculum has been proposed, but it has not …

Introduction: By the time an intervention is ready for evaluation in a definitive RCT the
context of the evidence base may have evolved. To avoid research waste, it is imperative …

Background: Interventional studies on polypharmacy often fail to significantly improve
patient-relevant outcomes, or confine themselves to measuring surrogate parameters …

Background: Current epidemiological situation has prompted the consideration of
multimorbility (MM) as a prevalent condition, influenced by age, educational level and social …

Background: As a result of ageing and advances in technology, people are living longer with
multiple co-morbidities, and are likely to take multiple medicines concurrently. This can lead …

Background: This thesis had two broad aims. The first aim was to modify a complex
potentially inappropriate prescribing (PIP) intervention in the context of a rapidly emerging …