Islet amyloid polypeptide: structure, function, and pathophysiology

R Akter, P Cao, H Noor, Z Ridgway… - Journal of diabetes …, 2016 - Wiley Online Library
The hormone islet amyloid polypeptide (IAPP, or amylin) plays a role in glucose
homeostasis but aggregates to form islet amyloid in type‐2 diabetes. Islet amyloid formation …

[HTML][HTML] Islet amyloid: from fundamental biophysics to mechanisms of cytotoxicity

P Cao, P Marek, H Noor, V Patsalo, LH Tu, H Wang… - FEBS letters, 2013 - Elsevier
Pancreatic islet amyloid is a characteristic feature of type 2 diabetes. The major protein
component of islet amyloid is the polypeptide hormone known as islet amyloid polypeptide …

Toxic oligomers and islet beta cell death: guilty by association or convicted by circumstantial evidence?

S Zraika, RL Hull, CB Verchere, A Clark, KJ Potter… - Diabetologia, 2010 - Springer
Type 2 diabetes is a progressive disease characterised by islet amyloid deposits in the
majority of patients. Amyloid formation is considered a significant factor in deterioration of …

Protein post‐translational modifications and misfolding: New concepts in heart failure

F Del Monte, G Agnetti - PROTEOMICS–Clinical Applications, 2014 - Wiley Online Library
A new concept in the field of heart‐failure (HF) research points to a role of misfolded
proteins, forming preamyloid oligomers (PAOs), in cardiac toxicity. This is largely based on …

Investigation of post-translational modifications in type 2 diabetes

B Chatterjee, SS Thakur - Clinical proteomics, 2018 - Springer
The investigation of post-translational modifications (PTMs) plays an important role for the
study of type 2 diabetes. The importance of PTMs has been realized with the advancement …