Traumatic brain injury: progress and challenges in prevention, clinical care, and research

AIR Maas, DK Menon, GT Manley, M Abrams… - The Lancet …, 2022 - thelancet.com
Executive summary Traumatic brain injury (TBI) has the highest incidence of all common
neurological disorders, and poses a substantial public health burden. TBI is increasingly …

Management of moderate to severe traumatic brain injury: an update for the intensivist

G Meyfroidt, P Bouzat, MP Casaer, R Chesnut… - Intensive care …, 2022 - Springer
Traumatic brain injury (TBI) remains one of the most fatal and debilitating conditions in the
world. Current clinical management in severe TBI patients is mainly concerned with …

Severe traumatic brain injury: targeted management in the intensive care unit

N Stocchetti, M Carbonara, G Citerio, A Ercole… - The Lancet …, 2017 - thelancet.com
Severe traumatic brain injury (TBI) is currently managed in the intensive care unit with a
combined medical–surgical approach. Treatment aims to prevent additional brain damage …

Serum neurofilament light protein predicts clinical outcome in traumatic brain injury

P Shahim, M Gren, V Liman, U Andreasson… - Scientific reports, 2016 - nature.com
Axonal white matter injury is believed to be a major determinant of adverse outcomes
following traumatic brain injury (TBI). We hypothesized that measurement of neurofilament …

[HTML][HTML] Machine learning algorithms performed no better than regression models for prognostication in traumatic brain injury

BY Gravesteijn, D Nieboer, A Ercole… - Journal of clinical …, 2020 - Elsevier
Objective We aimed to explore the added value of common machine learning (ML)
algorithms for prediction of outcome for moderate and severe traumatic brain injury. Study …

Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research

AIR Maas, DK Menon, PD Adelson, N Andelic… - The Lancet …, 2017 - thelancet.com
Executive summary A concerted effort to tackle the global health problem posed by traumatic
brain injury (TBI) is long overdue. TBI is a public health challenge of vast, but insufficiently …

Early management of severe traumatic brain injury

JV Rosenfeld, AI Maas, P Bragge… - The Lancet, 2012 - thelancet.com
Severe traumatic brain injury remains a major health-care problem worldwide. Although
major progress has been made in understanding of the pathophysiology of this injury, this …

Clustering identifies endotypes of traumatic brain injury in an intensive care cohort: a CENTER-TBI study

CAI Åkerlund, A Holst, N Stocchetti, EW Steyerberg… - Critical care, 2022 - Springer
Abstract Background While the Glasgow coma scale (GCS) is one of the strongest outcome
predictors, the current classification of traumatic brain injury (TBI) as 'mild','moderate'or …

Persistent problems 1 year after mild traumatic brain injury: a longitudinal population study in New Zealand

A Theadom, V Parag, T Dowell, K McPherson… - British Journal of …, 2016 - bjgp.org
Background Mild traumatic brain injury (mTBI) is a common problem in general practice
settings, yet previous research does not take into account those who do not attend hospital …

Aucubin alleviates oxidative stress and inflammation via Nrf2-mediated signaling activity in experimental traumatic brain injury

H Wang, XM Zhou, LY Wu, GJ Liu, WD Xu… - Journal of …, 2020 - Springer
Abstract Background Aucubin (Au), an iridoid glycoside from natural plants, has
antioxidative and anti-inflammatory bioactivities; however, its effects on a traumatic brain …