Neurodegenerative diseases are a heterogeneous group of disorders that are incurable and
characterized by the progressive degeneration of the function and structure of the central …

Lipids are a fundamental class of organic molecules implicated in a wide range of biological
processes related to their structural diversity, and based on this can be broadly classified …

Amyotrophic lateral sclerosis (ALS) was initially thought to be associated with oxidative
stress when it was first linked to mutant superoxide dismutase 1 (SOD1). The subsequent …

Circulating levels of undercarboxylated and bioactive osteocalcin double during aerobic
exercise at the time levels of insulin decrease. In contrast, circulating levels of osteocalcin …

Neurodegenerative diseases represent some of the most devastating neurological
disorders, characterized by progressive loss of the structure and function of neurons. Current …

In the fatal disease—amyotrophic lateral sclerosis (ALS)—upper (corticospinal) motor
neurons (MNs) and lower somatic MNs, which innervate voluntary muscles, degenerate …

PGC1α is a transcriptional coactivator that is a central inducer of mitochondrial biogenesis in
cells. Recent work highlighted that PGC1α can also modulate the composition and functions …

Members of the PGC‐1 family of coactivators have been revealed as key players in the
regulation of energy metabolism. Early gain‐and loss‐of‐function studies led to the …

Amyotrophic lateral sclerosis (ALS) is a fatal neurological disorder characterized by
progressive degeneration of motor neurons leading to skeletal muscle denervation. Earlier …

Neurodegenerative disorders are debilitating diseases of the brain, characterized by
behavioral, motor and cognitive impairments. Ample evidence underpins mitochondrial …