Inositol pyrophosphates are highly energetic inositol polyphosphate molecules present in
organisms from slime molds and yeast to mammals. Distinct classes of enzymes generate …

Inositol pyrophosphates (IPPs) are present in organisms ranging from plants, slime moulds
and fungi to mammals. Distinct classes of kinases generate different forms of energetic …

Inositol pyrophosphates belong to the diverse family of inositol polyphosphate species that
have a range of signaling functions. Since the discovery of inositol pyrophosphates in the …

Inositol pyrophosphates, also designated inositol diphosphates, possess high-energy β-
phosphates that can pyrophosphorylate proteins and regulate various cellular processes …

Inositol pyrophosphates have been implicated in numerous biological processes. Inositol
hexakisphosphate kinase-2 (IP6K2), which generates the inositol pyrophosphate …

Heat-shock proteins (HSPs) are abundant, inducible proteins best known for their ability to
maintain the conformation of proteins and to refold damaged proteins. Some HSPs …

Background Toll-like receptor 3 (TLR3) is a critical component of the innate immune
response to dsRNA viruses, which was considered to be mainly expressed in immune cells …

Background aims Many ovarian cancers originate from ovarian surface epithelium, where
they develop from cysts intermixed with stroma. The stromal layer is critical to the …

The stereochemistry of the inositol backbone provides a platform on which to generate a
vast array of distinct molecular motifs that are used to convey information both in signal …

Alzheimer's disease (AD) causes progressive, age-dependent cortical and hippocampal
dysfunction leading to abnormal intellectual capacity and memory. We propose a novel …