Innate immune responses to trauma
M Huber-Lang, JD Lambris, PA Ward - Nature immunology, 2018 - nature.com
Trauma can affect any individual at any location and at any time over a lifespan. The
disruption of macrobarriers and microbarriers induces instant activation of innate immunity …
disruption of macrobarriers and microbarriers induces instant activation of innate immunity …
Targeting immune cell checkpoints during sepsis
Immunosuppression is increasingly being recognized as one of the causes of increased
morbidity and mortality during sepsis. Both innate and adaptive immune system dysfunction …
morbidity and mortality during sepsis. Both innate and adaptive immune system dysfunction …
[HTML][HTML] Immune modulation after traumatic brain injury
Traumatic brain injury (TBI) induces instant activation of innate immunity in brain tissue,
followed by a systematization of the inflammatory response. The subsequent response …
followed by a systematization of the inflammatory response. The subsequent response …
[HTML][HTML] Cytotoxic immunity in peripheral nerve injury and pain
Cytotoxicity and consequent cell death pathways are a critical component of the immune
response to infection, disease or injury. While numerous examples of inflammation causing …
response to infection, disease or injury. While numerous examples of inflammation causing …
Development of a comprehensive antibody staining database using a standardized analytics pipeline
Large-scale immune monitoring experiments (such as clinical trials) are a promising
direction for biomarker discovery and responder stratification in immunotherapy. Mass …
direction for biomarker discovery and responder stratification in immunotherapy. Mass …
[HTML][HTML] A road map from single-cell transcriptome to patient classification for the immune response to trauma
Immune dysfunction is an important factor driving mortality and adverse outcomes after
trauma but remains poorly understood, especially at the cellular level. To deconvolute the …
trauma but remains poorly understood, especially at the cellular level. To deconvolute the …
Potential immune indicators for predicting the prognosis of COVID-19 and trauma: similarities and disparities
H Fouladseresht, A Ghamar Talepoor… - Frontiers in …, 2022 - frontiersin.org
Although cellular and molecular mediators of the immune system have the potential to be
prognostic indicators of disease outcomes, temporal interference between diseases might …
prognostic indicators of disease outcomes, temporal interference between diseases might …
Preferential inhibition of adaptive immune system dynamics by glucocorticoids in patients after acute surgical trauma
Glucocorticoids (GC) are a controversial yet commonly used intervention in the clinical
management of acute inflammatory conditions, including sepsis or traumatic injury. In the …
management of acute inflammatory conditions, including sepsis or traumatic injury. In the …
How clinical flow cytometry rebooted sepsis immunology
G Monneret, M Gossez, N Aghaeepour… - Cytometry Part …, 2019 - Wiley Online Library
Abstract On May 2017, the World Health Organization (WHO) recognized sepsis as a global
health priority by adopting a resolution to improve the prevention, diagnosis, and …
health priority by adopting a resolution to improve the prevention, diagnosis, and …
Inferring tissue-specific, TLR4-dependent type 17 immune interactions in experimental trauma/hemorrhagic shock and resuscitation using computational modeling
Trauma/hemorrhagic shock followed by resuscitation (T/HS-R) results in multi-system
inflammation and organ dysfunction, in part driven by binding of damage-associated …
inflammation and organ dysfunction, in part driven by binding of damage-associated …