This survey article addresses the class of continuous-time systems where a system modeled
by ordinary differential equations is coupled with a static or time-varying set-valued operator …

Cybergenetics is a novel field of research aiming at remotely pilot cellular processes in real-
time with to leverage the biotechnological potential of synthetic biology. Yet, the control of …

This article provides an overview of how three branches of science, namely Systems
Biology, Synthetic Biology and Control Theory might be interlaced to help solve relevant …

Microorganisms have evolved complex strategies for controlling the distribution of available
resources over cellular functions. Biotechnology aims at interfering with these strategies, so …

The problem of controlling cells endowed with a genetic toggle switch has been recently
highlighted as a benchmark problem in synthetic biology. It has been shown that a carefully …

In this letter, we analyze a genetic toggle switch recently studied in the literature where the
expression of two repressor proteins can be tuned by controlling two different inputs, namely …

The genetic toggle switch is a MIMO control system that can be controlled by varying the
concentrations of two inducer molecules, aTc and IPTG, to achieve a desired level of …

In this paper, the problem of robust stability of nonlinear genetic regulatory networks (GRNs)
is investigated. The developed method is an integral sliding mode control based redesign …

This chapter describes basic principles for modeling genetic regulatory networks, using
three different classes of formalisms: discrete, hybrid, and continuous differential systems. A …

We consider the problem of global stabilization of an unstable bioreactor model (eg, for
anaerobic digestion), when the measurements are discrete and in finite number …