With the increasing research and deepening understanding of the glioblastoma (GBM)
tumour microenvironment (TME), novel and more effective therapeutic strategies have been …

Tumor-associated mesenchymal stem/stromal cells (TA-MSCs) have been recognized as
attractive therapeutic targets in several cancer types, due to their ability to enhance tumor …

The prevalence and fatality rates of gastric cancer (GC) remain elevated, with advanced
stages presenting a grim prognosis. Noninvasive diagnosis of GC cancer often proves …

Glioblastoma (GBM) is the most common malignancy of the central nervous system in adults.
GBM has high levels of therapy failure and its prognosis is usually dismal. The phenotypic …

Background: Cancer-associated fibroblasts (CAFs) are found in primary and advanced
tumours. They are primarily involved in tumour progression through complex mechanisms …

The extracellular matrix (ECM) is a complex network of proteins and glycans, dynamically
remodeled and specifically tailored to the structure/function of each organ. The malignant …

Background Cancer associated fibroblasts (CAF), an important cancer-promoting and
immunosuppressive component of the tumor immune microenvironment (TIME), have …

Background Recent studies have identified the presence of cancer-associated fibroblasts
(CAFs) within glioblastoma (GBM), yet their biological roles and underlying mechanisms …

Glioblastoma (GBM) is an aggressive form of brain cancer that is highly resistant to therapy
due to significant intra-tumoral heterogeneity. The lack of robust in vitro models to study …

Complicated tumor microenvironment contributes mostly to chemoresistance in
glioblastoma. Glioma-associated fibroblasts (GAFs) were recently identified as non-tumor …