Immunology of bile acids regulated receptors
Bile acids are steroids generated at the interface of host and intestinal microbiota. While
primary bile acids are generated in the liver from cholesterol metabolism, secondary bile …
primary bile acids are generated in the liver from cholesterol metabolism, secondary bile …
Regulation of breast cancer metastasis signaling by miRNAs
Despite the decline in death rate from breast cancer and recent advances in targeted
therapies and combinations for the treatment of metastatic disease, metastatic breast cancer …
therapies and combinations for the treatment of metastatic disease, metastatic breast cancer …
MgFe‐LDH nanoparticles: a promising leukemia inhibitory factor replacement for self‐renewal and pluripotency maintenance in cultured mouse embryonic stem cells
X He, Y Zhu, L Yang, Z Wang, Z Wang… - Advanced …, 2021 - Wiley Online Library
Leukemia inhibitory factor (LIF), an indispensable bioactive protein that sustains self‐
renewal and pluripotency in stem cells, is vital for mouse embryonic stem cell (mESC) …
renewal and pluripotency in stem cells, is vital for mouse embryonic stem cell (mESC) …
Epithelial SOX9 drives progression and metastases of gastric adenocarcinoma by promoting immunosuppressive tumour microenvironment
Objective Many cancers engage embryonic genes for rapid growth and evading the immune
system. SOX9 has been upregulated in many tumours, yet the role of SOX9 in mediating …
system. SOX9 has been upregulated in many tumours, yet the role of SOX9 in mediating …
The emerging role of leukemia inhibitory factor in cancer and therapy
Leukemia inhibitory factor (LIF) is a multi-functional cytokine of the interleukin-6 (IL-6)
superfamily. Initially identified as a factor that inhibits the proliferation of murine myeloid …
superfamily. Initially identified as a factor that inhibits the proliferation of murine myeloid …
Targeting LIF/LIFR signaling in cancer
Leukemia inhibitory factor (LIF), and its receptor (LIFR), are commonly over-expressed in
many solid cancers and recent studies have implicated LIF/LIFR axis as a promising clinical …
many solid cancers and recent studies have implicated LIF/LIFR axis as a promising clinical …
IL-6 cytokine family: a putative target for breast cancer prevention and treatment
CM Felcher, ES Bogni, EC Kordon - International Journal of Molecular …, 2022 - mdpi.com
The IL-6 cytokine family is a group of signaling molecules with wide expression and function
across vertebrates. Each member of the family signals by binding to its specific receptor and …
across vertebrates. Each member of the family signals by binding to its specific receptor and …
Leukemia inhibitory factor, a double-edged sword with therapeutic implications in human diseases
Leukemia inhibitory factor (LIF) is a pleiotropic cytokine of the interleukin-6 (IL-6)
superfamily. LIF was initially discovered as a factor to induce the differentiation of myeloid …
superfamily. LIF was initially discovered as a factor to induce the differentiation of myeloid …
[HTML][HTML] New perspectives in cancer immunotherapy: targeting IL-6 cytokine family
Chronic inflammation has been recognized as a canonical cancer hallmark. It is
orchestrated by cytokines, which are master regulators of the tumor microenvironment (TME) …
orchestrated by cytokines, which are master regulators of the tumor microenvironment (TME) …
Leukemia inhibitory factor: an important cytokine in pathologies and cancer
MM Jorgensen, P de la Puente - Biomolecules, 2022 - mdpi.com
Leukemia Inhibitory Factor (LIF) is a member of the IL-6 cytokine family and is expressed in
almost every tissue type within the body. Although LIF was named for its ability to induce …
almost every tissue type within the body. Although LIF was named for its ability to induce …