We have reviewed the literature and have identified more than 100 diseases or conditions
that are associated with raised concentrations of plasma total homocysteine. The …

Hyperhomocysteinemia (HHcy) exerts a wide range of biological effects and is associated
with a number of diseases, including cardiovascular disease, dementia, neural tube defects …

Background Microglia-mediated neuroinflammation in Alzheimer's disease (AD) is not only a
response to pathophysiological events, but also plays a causative role in …

The aggregation of α‐synuclein plays a pivotal role in the pathogenesis of Parkinson's
disease (PD). Epidemiological evidence indicates that high level of homocysteine (Hcy) is …

Abstract Methyl-Cobalamin (Cbl) derives from dietary vitamin B12 and acts as a cofactor of
methionine synthase (MS) in mammals. MS encoded by MTR catalyzes the remethylation of …

In vitro cell culture is a routinely used method which is also applied for in vitro modeling of
various neurological diseases. On the other hand, media used for cell culture are often not …

Inherited disorders of B 12 metabolism produce a broad spectrum of manifestations, with
limited knowledge of the influence of age and the function of related genes. We report a …

Vascular dementia (VD) is the second leading cause of dementia after Alzheimer's disease
(AD). The decrease of cerebral blood flow (CBF) to different degrees is one of the main …

Abstract Background Hyperhomocysteinemia (HHcy) has been linked to development of
Alzheimer's disease (AD) neuropathologically characterized by the accumulation of amyloid …

DJ‐1, also known as Parkinson's disease protein 7 (Park7), is a multifunctional protein that
regulates oxidative stress and mitochondrial function. Dysfunction of DJ‐1 is implicated in …