Cytokines are a class of potent immunoregulatory proteins that are secreted in response to
various stimuli and act locally to regulate many aspects of human physiology and disease …

Purpose. Inflammation and tissue breakdown are led by an array of inflammatory destructive
mediators associated with initiation and progression of inflammatory diseases like …

Abstract Interleukin-21 (IL-21), an autocrine cytokine predominantly produced by follicular
helper T (Tfh) and T helper 17 (Th17) cells, has been proven to play an important role in the …

Our understanding of the role of T cells in human disease is undergoing revision as a result
of the discovery of T‐helper 17 (Th17) cells, a unique CD4+ T‐cell subset characterized by …

Preeclampsia is the leading cause of morbidity and mortality in pregnancy. Although the
etiology of preeclampsia is still unclear, it is believed to involve rejection of the fetus …

Naive CD4+ T cells give rise to T-helper-cell subsets with functions that are tailored to their
respective roles in host defence. The specification of T-helper-cell subsets is controlled by …

We demonstrate that CD161 is a highly up-regulated gene in human interleukin (IL) 17 T
helper cell (Th17) clones and that all IL-17–producing cells are contained in the CD161+ …

Interleukin‐21 (IL‐21) belongs to a family of cytokines that includes IL‐2, IL‐4, IL‐7, IL‐9,
and IL‐15, all of which bind to private (or shared) receptors as well as the common cytokine …

CD4+ T cells differentiate into various T helper subsets characterized by distinct cytokine
secreting profiles that confer them effector functions adapted to a variety of infectious or …

IL-21 is a relatively newly discovered immune-enhancing cytokine that plays an essential
role in controlling chronic viral infections. It is produced mainly by CD4+ T cells, which are …