Background FSGS caused by mutations in INF2 is characterized by a podocytopathy with
mistrafficked nephrin, an essential component of the slit diaphragm. Because INF2 is a …

Phosphatidylinositol-3-phosphate (PI3P), a major identity tag of early endosomes (EEs),
provides a platform for the recruitment of numerous cellular proteins containing an FYVE or …

Cytomegaloviruses (CMVs) extensively rearrange the cellular membrane system to develop
assembly compartment (AC), but the earliest events in this process are poorly characterized …

The overuse of antibiotics will led to the increase of drug resistance. Especially, the
multidrug-resistant A. baumannii became the leading cause of nosocomial infections with …

The deubiquitinating enzyme ubiquitin C-terminal hydrolase-L1 (UCH-L1) is required for the
maintenance of axonal integrity in neurons and is thought to regulate the intracellular pool of …

Murine cytomegalovirus (MCMV) initiates the stepwise establishment of the pre-assembly
compartment (pre-AC) in the early phase of infection by the expansion of the early …

Phagocytosis, macropinocytosis and antigen presentation by dendritic cells (DC) requires
reorganization of the actin cytoskeleton. Drebrin (Dbn1) is an actin binding and stabilizing …

Peripheral membrane proteins are endocytosed by constitutive processes of membrane
invaginations, followed by internalization driven by diverse endocytic machinery available at …

Affinity chromatography is a form of liquid chromatography that employs a biologically-
related binding agent as the stationary phase. This technique exploits the selective and …

Monoclonal antibodies, including bispecific antibodies, represent versatile platforms for
protein drug development. They have been successfully utilized for broad applications …