Regulation of antibiotic production in Actinobacteria: new perspectives from the post-genomic era

HU Van Der Heul, BL Bilyk, KJ McDowall… - Natural product …, 2018 - pubs.rsc.org
Covering: 2000 to 2018 The antimicrobial activity of many of their natural products has
brought prominence to the Streptomycetaceae, a family of Gram-positive bacteria that …

Chain release mechanisms in polyketide and non-ribosomal peptide biosynthesis

RF Little, C Hertweck - Natural Product Reports, 2022 - pubs.rsc.org
Review covering up to mid-2021 The structure of polyketide and non-ribosomal peptide
natural products is strongly influenced by how they are released from their biosynthetic …

The role of antibiotics and antibiotic resistance in nature

RI Aminov - Environmental microbiology, 2009 - Wiley Online Library
Investigations of antibiotic resistance from an environmental prospective shed new light on a
problem that was traditionally confined to a subset of clinically relevant antibiotic‐resistant …

Genomic basis for natural product biosynthetic diversity in the actinomycetes

M Nett, H Ikeda, BS Moore - Natural product reports, 2009 - pubs.rsc.org
Covering: up to mid-2009 The phylum Actinobacteria hosts diverse high G+ C, Gram-
positive bacteria that have evolved a complex chemical language of natural product …

Streptomyces morphogenetics: dissecting differentiation in a filamentous bacterium

K Flärdh, MJ Buttner - Nature Reviews Microbiology, 2009 - nature.com
During the life cycle of the filamentous bacteria Streptomyces, morphological differentiation
is closely integrated with fundamental growth and cell-cycle processes, as well as with truly …

The complex extracellular biology of Streptomyces

KF Chater, S Biró, KJ Lee, T Palmer… - FEMS microbiology …, 2010 - academic.oup.com
Streptomycetes, soil-dwelling mycelial bacteria that form sporulating aerial branches, have
an exceptionally large number of predicted secreted proteins, including many exported via …

The regulation of the secondary metabolism of Streptomyces: new links and experimental advances

GP Van Wezel, KJ McDowall - Natural product reports, 2011 - pubs.rsc.org
Covering: up to early 2011 Streptomycetes and other actinobacteria are renowned as a rich
source of natural products of clinical, agricultural and biotechnological value. They are being …

Natural products in soil microbe interactions and evolution

MF Traxler, R Kolter - Natural product reports, 2015 - pubs.rsc.org
Covering: up to 2015 In recent years, bacterial interspecies interactions mediated by small
molecule natural products have been found to give rise to a surprising array of phenotypes …

Angucyclines: Biosynthesis, mode-of-action, new natural products, and synthesis

MK Kharel, P Pahari, MD Shepherd, N Tibrewal… - Natural product …, 2012 - pubs.rsc.org
Covering: 1997 to 2010 The angucycline group is the largest group of type II PKS-
engineered natural products, rich in biological activities and chemical scaffolds. This …

Natural products from reconstructed bacterial genomes of the Middle and Upper Paleolithic

M Klapper, A Hübner, A Ibrahim, I Wasmuth, M Borry… - Science, 2023 - science.org
Major advances over the past decade in the field of ancient DNA are providing access to
past paleogenomic diversity, but the diverse functions and biosynthetic capabilities of this …