The OXA β-lactamases were among the earliest β-lactamases detected; however, these
molecular class D β-lactamases were originally relatively rare and always plasmid …

Acinetobacter baumannii is a common cause of serious nosocomial infections. Although
community-acquired infections are observed, the vast majority occur in people with …

Resistance to available antibiotics in pathogenic bacteria is currently a global challenge
since the number of strains that are resistant to multiple types of antibiotics has increased …

Antibiotic resistance, and the emergence of pan-resistant clinical isolates, seriously
threatens our capability to treat bacterial diseases, including potentially deadly hospital …

Infections caused by resistant bacteria are nowadays too common, and some pathogens
have even become resistant to multiple types of antibiotics, in which case few or even no …

Carbapenem resistance is a major global health problem that seriously compromises the
treatment of infections caused by nosocomial pathogens. Resistance to carbapenems …

As the incidence of Gram-negative bacterial infections for which few effective treatments
remain increases, so does the contribution of drug-hydrolyzing β-lactamase enzymes to this …

Infect Dis Clin N Am 30 (2016) 441–464 http://dx. doi. org/10.1016/j. idc. 2016.02. 007 id.
theclinics. com 0891-5520/16/$–see front matter© 2016 Elsevier Inc. All rights reserved …

Acinetobacter spp. are Gram-negative bacteria that have become one of the most difficult
pathogens to treat. The species A. baumannii, largely unknown 30 years ago, has risen to …

Limited treatment options exist to combat infections caused by multidrug-resistant (MDR)
Gram-negative bacteria possessing broad-spectrum β-lactamases. The design of novel β …